Testicular Versus Ejaculated Spermatozoa for IVF/ICSI in Men With High Sperm DNA Damage

Randomized Control Trial on the Use of Testicular Versus Ejaculated Spermatozoa for IVF/ICSI on Pregnancy Outcomes for Men With High Sperm DNA Damage

The purpose of this study is to determine whether couples undergoing IVF/ICSI with male factor infertility, specifically with elevated sperm DNA damage, should testicular sperm extraction be utilized to improve their reproductive outcomes.

Inclusion Criteria:

• ≥18 years of age
• be considered infertile (>1 year of unsuccessful attempts of conception
• Any race
• Male partner with persistent sperm DNA damage, DFI>=30%
• candidates for intracytoplasmic sperm injection (ICSI)

Exclusion Criteria:

• significant female factor infertility contributing to the couple's infertility
• female partner older than 38 years
• male or female patients with genetic abnormalities
• patients unable or unwilling to give consent after properly informed
• couples unsuitable for IVF/ICSI
• male patients in whom testicular procedures were contraindicated