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There is evidence indicating that sperm plays a role in determining blastocyst ploidy status. In our study, we aim to compare the outcomes of preimplantation genetic testing for aneuploidy (PGT-A) and the subsequent clinical outcomes following transfers of euploid embryos. This comparison will be conducted between cases where ejaculated sperm and cases where testicular sperm were used for intracytoplasmic sperm injection (ICSI), specifically focusing on severe male factor infertility patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ejaculate | Active Comparator | Patients within this arm will undergo ICSI utilizing ejaculated sperm. |
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| Testicular | Active Comparator | Patients within this arm will undergo ICSI utilizing testicular sperm. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Testicular sperm extraction (TESE) | Procedure | Surgical procedure used to retrieve sperm directly from the testicles of men who have low sperm production or no sperm in their ejaculate |
| Measure | Description | Time Frame |
|---|---|---|
| Euploidy rate | Defined as the proportion of euploid blastocysts | 15 days post ICSI |
| Aneuploidy rate | Defined as the proportion of aneuploid blastocysts | 15 days post ICSI |
| Low mosaic rate | Defined as the proportion of low mosaic blastocysts | Time Frame: 15 days post ICSI |
| High mosaic rate | Defined as the proportion of high mosaic blastocysts | Time Frame: 15 days post ICSI |
| Implantation rate | defined as the percentage of successfully implanted embryos | 6-9 weeks post-embryo transfer |
| Ongoing pregnancy rate | defined as a positive heartbeat on ultrasound beyond 12 weeks of gestation | 12 weeks of gestation |
| Miscarriage rate | defined as pregnancy loss following confirmation of clinical pregnancy | after 6 weeks of gestation |
| Clinical pregnancy rate | defined as the presence of a fetal heartbeat or gestational sac 6-9 weeks post-embryo transfer | 6-9 weeks post-embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| Fertilization rate | Defined as the proportion of fertilizaed oocytes | 1 day |
| Cleavage rate | Defined as the proportion of cleaved embryos on day 3 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eman Hasanen | Ganin Fertility Center | Principal Investigator |
| Hosam Zaki, FRCOG | Ganin Fertility Center | Study Chair |
| Refaat Gabre, PhD | Faculty of Science, Cairo University | Study Director |
| Mohamed Abbas | Cairo University | Study Chair |
| Nahla Osama, Phd | Faculty of Science, Cairo University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ganin Fertility Center | Cairo | Maadi | 11728 | Egypt |
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| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| ID | Term |
|---|---|
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007246 | Infertility |
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| Ejaculate | Other | Ejaculate processing for ICSI |
|
| 3 days |
| Blastocyst development rate | Defined as the proportion of blastocysts formed on day 5 or 6 | 5-6 days |
| D052801 |
| Male Urogenital Diseases |