Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures

Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural cycle (luteinizing hormone, LH). In a natural cycle another hormone takes part in the process (follicle stimulating hormone, FSH). To induce a natural-like ovulation surge that includes LH and FSH , gonadotropin releasing hormone (GnRH) agonist can be given.

The purpose of this study is to find out which approach may work better in IVF patients who experienced 4 IVF failures.

Inclusion Criteria:

• IVF patients with at least 4 consecutive failures.
• On trigger day, no more than 10 follicles of 12 mm and up

Exclusion Criteria:

• History of moderate or severe OHSS.