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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-000960-26 |
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Comparing a pharmacokinetic model of a short sevoflurane sedation in burn ICU patients with control ICU patients.
Prospective clinical study in ICU with sedated ventilated patients with sevoflurane with the AnaConda® system, establishing pharmacokinetic model of sevoflurane and its metabolites (hydroxyfluroisopropanol, fluoride) comparing burn and non burn ICU patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| burn ICU patients | Experimental | Determination of plasmatic concentrations of sevoflurane at different times of a short term sedation of sevoflurane in burn versus non burn ICU patients |
|
| non burn ICU patients | Other | Determination of plasmatic concentrations of sevoflurane at different times of a short term sedation of sevoflurane in burn versus non burn ICU patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Short term sedation with sevoflurane in ICU | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Determination of plasmatic concentrations of sevoflurane | at 5min, 15 min, 60 min and just before the end of sedation. |
| Measure | Description | Time Frame |
|---|---|---|
| Determination of plasmatic concentrations of HFIP and fluoride | at 5min, 15 min, 60 min and just before the end of sedation. And 5min, 10 min, 30 min, 60 min and 120 min after the end of sedation |
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Inclusion Criteria:
Adult patients ventilated requiring invasive procedure in ICU
Exclusion Criteria:
BMI <30
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| Name | Affiliation | Role |
|---|---|---|
| Sébastien PERBET | University Hospital, Clermont-Ferrand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Clermont-Ferrand | Clermont-Ferrand | 63003 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29455032 | Derived | Perbet S, Bourdeaux D, Lenoire A, Biboulet C, Pereira B, Sadoune M, Plaud B, Launay JM, Bazin JE, Sautou V, Mebazaa A, Houze P, Constantin JM, Legrand M; PRONOBURN group. Sevoflurane for procedural sedation in critically ill patients: A pharmacokinetic comparative study between burn and non-burn patients. Anaesth Crit Care Pain Med. 2018 Dec;37(6):551-556. doi: 10.1016/j.accpm.2018.02.001. Epub 2018 Feb 15. |
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| ID | Term |
|---|---|
| D002056 | Burns |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| D007362 | Intensive Care Units |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
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| D006846 |
| Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D006757 | Hospital Units |
| D006268 | Health Facilities |
| D005159 | Health Care Facilities Workforce and Services |