A Pharmacokinetic Study of Sevoflurane Inhalation in Burn ICU Patients

A Pharmacokinetic Study of Sevoflurane Inhalation in Burn ICU Patients

Comparing a pharmacokinetic model of a short sevoflurane sedation in burn ICU patients with control ICU patients.

Prospective clinical study in ICU with sedated ventilated patients with sevoflurane with the AnaConda® system, establishing pharmacokinetic model of sevoflurane and its metabolites (hydroxyfluroisopropanol, fluoride) comparing burn and non burn ICU patients

Inclusion Criteria:

• Adult patients ventilated requiring invasive procedure in ICU

  • Stable respiratory and hemodynamic conditions
  • Consent of patients or family
  • Arterial line
  • Burn patients : burn area between 20 and 50% (3rd degree) OR non burn patients

Exclusion Criteria:

• BMI <30

  • Sevoflurane anaphylaxia