Pharmacokinetic of Sevoflurane During a 48h Sedation in Intensive Care Unit With AnaConDa®

Pharmacokinetic of Sevoflurane During a 48h Sedation in ICU With AnaConDa®

This is a prospective clinical monocentric study in ICU with sedated ventilated patients with sevoflurane during 48 h with the AnaConda® system, establishing pharmacokinetic model of sevoflurane.

Prospective clinical monocentric study in ICU with sedated ventilated patients with sevoflurane during 48 h with the AnaConda® system, establishing pharmacokinetic model of sévoflurane and its metabolites (hydroxyfluroisopropanol, fluoride)

Inclusion Criteria:

• Adult patients ventilated more than 48 h
• Stable respiratory and hemodynamic conditions
• Consent of patients or family
• Arterial line

Exclusion Criteria:

• Acute kidney injury
• Obesity
• Sevoflurane anaphylaxia