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The aim of this study is to evaluate calcium ionophore solution on fertilization rate of patients during intracytoplasmic sperm injection who have poor ovarian reserve
During ICSI cycle , female patients who have poor ovarian reserve have low oocyte numbers. So by calcium ionophore solution which we know that it can increase fertilization rate in males who have azospermia or globozoospermia. we planned to check if this solution can increase fertilization rate also in poor ovarian reserve patients?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | No Intervention | the patients who have no intervention with calcium ionophore during ICSI cycle | |
| calcium ionophore | Experimental | the patients whose oocytes are incubated with calcium ionophore solution during ICSI cycle |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| calcium ionophore solution | Other | After microinjection of sperm into the oocyte, oocytes are incubated for 15 minutes in a 30 microlitre droplet of calcium ionomycin solution |
|
| Measure | Description | Time Frame |
|---|---|---|
| calcium ionophore solution effect on fertilization rate | Before Intracytoplasmic sperm injection adding calcium ionophore solution to the medium can increase fertilization rate of oocytes or not? | 18 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Calcium ionophore solution increase on going pregnancy rate | Ä°f the calcium ionophore can increase fertilization rate , pregnancy rate up to 20 weeks, can increase or not? | up to 21 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| calcium ionophore can decrease fertilization rate | To detect if calcium ionophore can affect fertilization rate in a reverse manner than expected | 18 hours |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pinar Caglar Aytac, MD | Contact | 905052796784 | pinarcag1976@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| esra bulgan kilicdag, prof md | Baskent University | Study Director |
| Huriye Ayse Parlakgumus, md | Baskent University | Study Chair |
| Pinar Caglar Aytac, md |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| baskent university obstetric and gynecology, reproductive endocrinology and IVF unit | Recruiting | Adana | Kisla | 01230 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26342247 | Derived | Caglar Aytac P, Kilicdag EB, Haydardedeoglu B, Simsek E, Cok T, Parlakgumus HA. Can calcium ionophore "use" in patients with diminished ovarian reserve increase fertilization and pregnancy rates? A randomized, controlled study. Fertil Steril. 2015 Nov;104(5):1168-74. doi: 10.1016/j.fertnstert.2015.07.1163. Epub 2015 Sep 3. |
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|
| Baskent University |
| Principal Investigator |
| Cok Tayfun, md | Baskent University | Study Chair |
| Bulent Haydardedeoglu, assoc Prof | Baskent University | Study Chair |
| Erhan Simsek, md | Baskent University | Study Chair |
| ID | Term |
|---|---|
| D015759 | Ionomycin |
| ID | Term |
|---|---|
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
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