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Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional ICSI | Active Comparator | The couple showed complete fertilization failure after ICSI. |
|
| Convention ICSI | Active Comparator | The couple showed a low fertilization rates after ICSI. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Calcium ionophore | Other | Oocytes were activated with calcium ionophore after ICSI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fertilization rate | 18 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Embryo quality | 3 Days | |
| Pregnancy and Implantation rates | 2 months | |
| Assessment of Infant health care |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maria Fertility Hospital | Seoul | 138-160 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25592974 | Derived | Kim JW, Yang SH, Yoon SH, Kim SD, Jung JH, Lim JH. Successful pregnancy and delivery after ICSI with artificial oocyte activation by calcium ionophore in in-vitro matured oocytes: a case report. Reprod Biomed Online. 2015 Apr;30(4):373-7. doi: 10.1016/j.rbmo.2014.11.014. Epub 2014 Dec 11. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D061207 | Calcium Ionophores |
| C025700 | strontium chloride |
| ID | Term |
|---|---|
| D007476 | Ionophores |
| D049990 | Membrane Transport Modulators |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
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| Strontium chloride (SrCl2) | Other | Oocytes were activated with strontium chloride after ICSI |
|
This assessment is according to the standard set by the National Health Insurance Service (NHIS) in Korea.
| birth and at 3, 6, 12, 24, 36, 60, and 72 months |
| D020164 | Chemical Actions and Uses |
| D020313 | Specialty Uses of Chemicals |