Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents

Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents

The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.

The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.

Inclusion Criteria:

• caucasian youth
• pubertal Tanner stage x, y, or z

Exclusion Criteria:

• fasting plasma glucose > 7.0 mmol/L
• significant illness
• taking medications