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| Name | Class |
|---|---|
| University Children's Hospital Basel | OTHER |
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The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.
The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test meal (500 kcal)_normal weight | Placebo Comparator | ham sandwich chocolate cream orange juice |
|
| Test meal (500 kcal)_obese weight | Active Comparator | ham sandwich chocolate cream orange juice |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| test meal (500 kcal) | Dietary Supplement | whole wheat bread (68 g), butter(10 g), ham (25 g); chocolate cream (90 g); orange juice (200 mL) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of gastrointestinal peptide secretion in normal weight and obese adolescents | Relation of GLP-1 release to insulin secretion in normal weight and obese adolescents | 2 hours blood sampling |
| Measure | Description | Time Frame |
|---|---|---|
| Association between gastrointestinal peptides and insulin release | Dynamics of gastrointestinal peptide secretion including Tmax and Cmax | 2 hours blood sampling |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Beglinger, MD | Division of Gastroenterology and Hepatology, University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel, Division of Gastroenterology and Hepatology | Basel | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
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| test meal (500 kcal) | Dietary Supplement | whole wheat bread (68 g), butter(10 g), ham (25 g); chocolate cream (90 g); orange juice (200 mL) |
|