Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal

Identification of Nutritional Health Biomarkers for Metabolic Flexibility in Blood - a Randomized, Postprandial, Caloric Dose-response Strategy

The study will quantitatively evaluate the metabolic response of normal weight and obese subjects to three high-fat meals differing in caloric dose by analysing the postprandial blood transcriptome.

Inclusion Criteria for normal weight subjects:

• age 25-50
• 20<BMI>25
• waist circumference <94cm

Inclusion Criteria for obese subjects:

• age 25-50
• 30<BMI>40
• waist circumference >102cm

Exclusion Criteria for both groups:

• physiological or psychological diseases
• allergies to food or intolerance to high-fat meal
• vegetarians, vegans
• chronic intake of drugs
• smokers
• diabetes mellitus type I and II
• debiliating kidney disease
• debiliating liver disease
• clinically established coronary heart diseases
• ingestion of vitamins or dietary supplements during the course of the study