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| Name | Class |
|---|---|
| Insel Gruppe AG, University Hospital Bern | OTHER |
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The purpose of this study is to quantify the systemic inflammatory and metabolic response of lean subjects and obese subjects to the ingestion of three caloric doses of a high-fat meal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lean Subjects | Experimental |
| |
| Obese subjects | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-fat meal | Dietary Supplement | Three caloric doses of high-fat meal (500, 1000, 1500 kcal) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Interleukin-6 (serum) | A statistically-significant increase in serum Interleukin-6 is expected at 4h compared to 0h | 4h vs 0h |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose (serum) | 0h, 1h, 2h, 4h, 6h | |
| Triglyceride (serum) | 0h, 1h, 2h, 4h, 6h | |
| Insulin (serum) |
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Inclusion Criteria for lean subjects:
Inclusion Criteria for obese subjects
Exclusion Criteria for lean and obese subjects:
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| Name | Affiliation | Role |
|---|---|---|
| Kurt Laederach, MD | Inselspital University of Berne | Study Director |
| Katrin Bolanz, PhD | Agroscope Liebefeld-Posieux ALP Research Station | Principal Investigator |
| Flurina Schwander, M.Sc. | Agroscope Liebefeld-Posieux ALP Research Station | Principal Investigator |
| Caroline Buri, MD | Inselspital University of Berne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Agroscope Liebefeld-Posieux ALP Research Station | Bern | Canton of Bern | 3003 | Switzerland | ||
| University Hospital Inselspital, Berne |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24812072 | Derived | Schwander F, Kopf-Bolanz KA, Buri C, Portmann R, Egger L, Chollet M, McTernan PG, Piya MK, Gijs MA, Vionnet N, Pralong F, Laederach K, Vergeres G. A dose-response strategy reveals differences between normal-weight and obese men in their metabolic and inflammatory responses to a high-fat meal. J Nutr. 2014 Oct;144(10):1517-23. doi: 10.3945/jn.114.193565. Epub 2014 May 8. |
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| ID | Term |
|---|---|
| D009750 | Nutritional and Metabolic Diseases |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
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| 0h, 1h, 2h, 4h, 6h |
| high sensitivity C-Reactive Protein | 0h, 1h, 2h, 4h, 6h |
| HDL-cholesterol | 0h, 1h, 2h, 4h, 6h |
| Total cholesterol | 0h, 1h, 2h, 4h, 6h |
| Total cholesterol / HDL cholesterol | 0h, 1h, 2h, 4h, 6h |
| Interleukin-6 (serum) | 0h, 1h, 2h, 4h, 6h |
| Glucagon-like-protein-1 (serum) | 0h, 1h 2h, 4h, 6h |
| Endotoxin (serum) | 0h, 1h, 2h, 4h, 6h |
| Bern |
| Canton of Bern |
| 3010 |
| Switzerland |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |