Comparison of Postprandial Inflammation in Lean and Obese Subjects

The purpose of this study is to quantify the systemic inflammatory and metabolic response of lean subjects and obese subjects to the ingestion of three caloric doses of a high-fat meal.

Inclusion Criteria for lean subjects:

• age 25-50
• 20<BMI<25
• waist circumference <94cm

Inclusion Criteria for obese subjects

• age-matched to healthy subjects
• 30<BMI<40
• waist circumference >102cm

Exclusion Criteria for lean and obese subjects:

• Physiological or psychological diseases
• Allergies to food or intolerance to high-fat meal
• Vegetarians
• Chronic intake of drugs
• Smokers
• Diabetes mellitus Type I and II
• Debilitating kidney diseases
• Debilitating liver diseases
• Clinically established coronary heart diseases
• Ingestion of vitamins or dietary supplements during the course of the study