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| Name | Class |
|---|---|
| Insel Gruppe AG, University Hospital Bern | OTHER |
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The study will quantitatively evaluate the systemic, postprandial inflammatory and metabolic response to the ingestion of three different meals in obese subjects. The administered meals will differ in the proportion of dairy products. Postprandial response will be monitored during 6 hours after meal consumption.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high fat meal without dairy products | Active Comparator | high fat meal without dairy products |
|
| high fat meal with additional milk | Experimental | high fat meal with additional milk |
|
| dairy product meal | Experimental | dairy product meal |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| consumption of test meal based on dairy products | Other |
| ||
| consumption of high fat test meal without dairy products |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammation markers in blood plasma (IL-6, TNF-alpha) | 0,6h |
| Measure | Description | Time Frame |
|---|---|---|
| Biomarkers in blood (serum insulin, plasma glucose, GLP-1, lipids) | 0,1,2,4,6h | |
| Endotoxin in blood serum | 0,6h |
| Measure | Description | Time Frame |
|---|---|---|
| Blood cell transcriptome | 0,2,4,6h | |
| blood serum metabolome | 0,2,4,6h |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kur Laederach, MD | Insel Gruppe AG, University Hospital Bern | Principal Investigator |
| Alexandra Schmid | Agroscope Liebefeld-Posieux ALP | Study Director |
| Caroline Buri, MD, PhD | Insel Gruppe AG, University Hospital Bern | Study Director |
| Guy Vergères, PhD | Agroscope Liebefeld-Posieux ALP | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital, Inselspital Berne | Bern | Canton of Bern | 3010 | Switzerland |
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| Other |
|
| consumption of high fat test meal with dairy products | Other |
|
| ID | Term |
|---|---|
| D007249 | Inflammation |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D003611 | Dairy Products |
| ID | Term |
|---|---|
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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