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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
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Curcumin, a lipophilic polyphenol derived from the plant curcuma longa possesses numerous health-promoting activities. The oral bioavailability of curcumin is low due to its poor aqueous solubility, limited gastrointestinal absorption, rapid metabolism and excretion. Therefore, we tested, in a randomized crossover study, simultaneous application of phytochemicals and micellar solubilisation, alone and together, as strategies to enhance the absorption of curcumin into the body. Furthermore, we investigated age and sex differences in curcumin pharmacokinetics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Native curcumin | Active Comparator | 80 mg curcumin as native powder |
|
| Native curcumin plus phytochemicals | Experimental | 80 mg curcumin as native powder plus 80 mg sesamin, 40 mg naringenin, 40 mg ferulic acid and 40 mg xanthohumol |
|
| Curcumin micelles | Experimental | 80 mg curcumin incorporated into liquid micelles |
|
| Curcumin micelles plus phytochemicals | Experimental | 80 mg curcumin incorporated into liquid micelles plus 80 mg sesamin, 40 mg naringenin, 40 mg ferulic acid, 40 mg xanthohumol incorporated into micelles |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| curcumin | Dietary Supplement | 80 mg curcumin were given orally either as native powder, native powder plus phytochemicals,micelles or micelles plus phytochemicals |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under the plasma concentration versus time curve (AUC) of total curcumin [nmol/L*h] | Total curcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| Area under the plasma concentration versus time curve (AUC) of total demethoxycurcumin [nmol/L*h] | Total demethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| Area under the plasma concentration versus time curve (AUC) of total bisdemethoxycurcumin [nmol/L*h] | Total bisdemethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| Maximum plasma concentration (Cmax) of total curcumin [nmol/L] | Total curcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| Maximum plasma concentration (Cmax) of total demethoxycurcumin [nmol/L] | Total demethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| Maximum plasma concentration (Cmax) of total bisdemethoxycurcumin [nmol/L] | Total bisdemethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| Time to reach maximum plasma concentration (Tmax) of total curcumin [h] |
| Measure | Description | Time Frame |
|---|---|---|
| Serum aspartate transaminase activity [U/L] | 0, 4, 24h post-dose | |
| Serum alanine transaminase activity [U/L] | 0, 4, 24h post-dose | |
| Serum gamma-glutamyl transferase activity [U/L] |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan Frank, Ph.D. | University of Hohenheim, Stuttgart, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Hohenheim | Stuttgart | Baden-Wurttemberg | 70599 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | Kocher, A., Schiborr, C., Behnam, D., & Frank, J. (2015). The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin, ferulic acid, naringenin and xanthohumol. J Funct Foods 14: 183-19. |
| Label | URL |
|---|---|
| Website of the research group | View source |
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| ID | Term |
|---|---|
| D003474 | Curcumin |
| ID | Term |
|---|---|
| D036381 | Diarylheptanoids |
| D006536 | Heptanes |
| D000473 | Alkanes |
| D006839 | Hydrocarbons, Acyclic |
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Total curcumin was determined after deconjugation with beta-glucuronidase/sulphatase |
| 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| Time to reach maximum plasma concentration (Tmax) of total demethoxycurcumin [h] | Total demethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| Time to reach maximum plasma concentration (Tmax) of total bisdemethoxycurcumin [h] | Total bisdemethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post-dose |
| 0, 4, 24h post-dose |
| Serum alkaline phosphatase activity [U/L] | 0, 4, 24h post-dose |
| Serum bilirubin [mg/dL] | 0, 4, 24h post-dose |
| Serum uric acid [mg/dL] | 0, 4, 24h post-dose |
| Serum creatinine [mg/dL] | 0, 4, 24h post-dose |
| Serum total cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum HDL cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum LDL cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum triacylglycerols [mg/dL] | 0, 4, 24h post-dose |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |