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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
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Background: The oral bioavailability of curcumin is low due to its limited intestinal uptake, rapid metabolism and excretion from the body. Considering its potent reported health-beneficial properties, researchers have tried to increase its bioavailability as a means to enhance its biological activities.
Objective: The aim of the project was to develop novel curcumin formulations with enhanced oral bioavailability and to study the safety of the formulations and potential sex-differences in humans.
Design: In this single-blind crossover study with three arms separated by ≥1-week washout periods, healthy subjects (13 women, 10 men) were provided standardized meals and took, in random order, a single oral dose of 500 mg curcumin as native powder, micronized powder, or liquid micelles. Blood and urine samples were collected in intervals for 24 h and total curcumin, demethoxycurcumin, and bis-demethoxycurcumin were quantified.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Native curcumin powder | Active Comparator | 500 mg curcumin as native powder |
|
| Micronized curcumin powder | Experimental | 500 mg curcumin as micronized powder |
|
| Curcumin micelles | Experimental | 500 mg curcumin incorporated into liquid micelles |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| curcumin | Dietary Supplement | 500 mg curcumin were given orally either as native powder, micronized powder, or liquid micelles |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under the plasma concentration versus time curve (AUC) of total curcumin [nmol/L*h] | Total curcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| Area under the plasma concentration versus time curve (AUC) of total demethoxycurcumin [nmol/L*h] | Total demethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| Area under the plasma concentration versus time curve (AUC) of total bisdemethoxycurcumin [nmol/L*h] | Total bisdemethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| Maximum plasma concentration (Cmax) of total curcumin [nmol/L] | Total curcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| Maximum plasma concentration (Cmax) of total demethoxycurcumin [nmol/L] | Total demethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| Maximum plasma concentration (Cmax) of total bisdemethoxycurcumin [nmol/L] | Total bisdemethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| Measure | Description | Time Frame |
|---|---|---|
| Serum aspartate transaminase activity [U/L] | Baseline | |
| Serum aspartate transaminase activity [U/L] | 4 h post-dose | |
| Serum aspartate transaminase activity [U/L] |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan Frank, Ph.D. | University of Hohenheim, Stuttgart, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Hohenheim | Stuttgart | 70599 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24402825 | Result | Schiborr C, Kocher A, Behnam D, Jandasek J, Toelstede S, Frank J. The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res. 2014 Mar;58(3):516-27. doi: 10.1002/mnfr.201300724. Epub 2014 Jan 9. |
| Label | URL |
|---|---|
| Website of the research group | View source |
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| ID | Term |
|---|---|
| D003474 | Curcumin |
| ID | Term |
|---|---|
| D036381 | Diarylheptanoids |
| D006536 | Heptanes |
| D000473 | Alkanes |
| D006839 | Hydrocarbons, Acyclic |
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| Time to reach maximum plasma concentration (Tmax) of total curcumin [h] |
Total curcumin was determined after deconjugation with beta-glucuronidase/sulphatase |
| 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| Time to reach maximum plasma concentration (Tmax) of total demethoxycurcumin [h] | Total demethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| Time to reach maximum plasma concentration (Tmax) of total bisdemethoxycurcumin [h] | Total bisdemethoxycurcumin was determined after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 1.5, 2, 4, 6, 8 and 24 h post-dose |
| 24 h post-dose |
| Serum alanine transaminase activity [U/L] | Baseline |
| Serum alanine transaminase activity [U/L] | 4 h post-dose |
| Serum alanine transaminase activity [U/L] | 24 h post-dose |
| Serum gamma-glutamyl transferase activity [U/L] | Baseline |
| Serum gamma-glutamyl transferase activity [U/L] | 4 h post-dose |
| Serum gamma-glutamyl transferase activity [U/L] | 24 h post-dose |
| Serum alkaline phosphatase activity [U/L] | Baseline |
| Serum alkaline phosphatase activity [U/L] | 4 h post-dose |
| Serum alkaline phosphatase activity [U/L] | 24 h post-dose |
| Serum bilirubin [mg/dL] | Baseline |
| Serum bilirubin [mg/dL] | 4 h post-dose |
| Serum bilirubin [mg/dL] | 24 h post-dose |
| Serum uric acid [mg/dL] | Baseline |
| Serum uric acid [mg/dL] | 4 h post-dose |
| Serum uric acid [mg/dL] | 24 h post-dose |
| Serum cystatin C [mg/L] | Baseline |
| Serum cystatin C [mg/L] | 4 h post-dose |
| Serum cystatin C [mg/L] | 24 h post-dose |
| Glomerular filtration rate [mL/min] | Baseline |
| Glomerular filtration rate [mL/min] | 4 h post-dose |
| Glomerular filtration rate [mL/min] | 24 h post-dose |
| Serum creatinine [mg/dL] | Baseline |
| Serum creatinine [mg/dL] | 4 h post-dose |
| Serum creatinine [mg/dL] | 24 h post-dose |
| Serum total cholesterol [mg/dL] | Baseline |
| Serum total cholesterol [mg/dL] | 4 h post-dose |
| Serum total cholesterol [mg/dL] | 24 h post-dose |
| Serum HDL cholesterol [mg/dL] | Baseline |
| Serum HDL cholesterol [mg/dL] | 4 h post-dose |
| Serum HDL cholesterol [mg/dL] | 24 h post-dose |
| Serum LDL cholesterol [mg/dL] | Baseline |
| Serum LDL cholesterol [mg/dL] | 4 h post-dose |
| Serum LDL cholesterol [mg/dL] | 24 h post-dose |
| Serum triacylglycerols [mg/dL] | Baseline |
| Serum triacylglycerols [mg/dL] | 4 h post-dose |
| Serum triacylglycerols [mg/dL] | 24 h post-dose |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |