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| Name | Class |
|---|---|
| Danisco | INDUSTRY |
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The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.
Based on previous scientific results we hypotesize, that pentoses decreases the demand for insulin in metabolizing a given dose of sucrose.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0% pentose | Placebo Comparator | Pure sucrose without pentoses added. |
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| 4% D-xylose | Active Comparator | Sucrose drink supplemented with 4% D-xylose |
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| 8% D-xylose | Active Comparator | Sucrose drink supplemented with 8% D-xylose |
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| 8% L-arabinose | Active Comparator | Sucrose drink supplemented with 8% L-arabinose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo comparator: 0% pentose | Dietary Supplement | 14 healthy subjects participated in a randomized double-blinded cross-over study based on four single tests. Sucrose containing drinks were supplemented with two different doses of D-xylose and in addition one dose of L-arabinose was included for comparison with earlier studies. Blood was collected fasting and for 3-h postprandially. Appetite sensations and energy intake were registered. Gastrointestinal symptoms were monitored for 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose, insulin, C-peptide and GLP-1 | Level of glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) over time, the area under the curve (AUC), the peak value and time to peak | -15, 0, 15, 30, 45, 60, 90, 120, 180 min |
| Measure | Description | Time Frame |
|---|---|---|
| Appetite measurements and energy intake | Appetite measurements: area under/over the curve (AUC/AOC), 3-h mean. Energy intake: the ad libitum energy intake at lunch was registered. VAS was used to asses the palatability (appearance, smell, taste, after-taste and overall palatability) of the ad libitum lunch. | -15, 30, 60, 90, 120, 150 and 180 min |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jens R Andersen, MD,MPA | University of Copenhagen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Human Nutrition, The Royal Veterinary and Agricultural University | Frederiksberg | DK-1958 | Denmark |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D010429 | Pentoses |
| D014994 | Xylose |
| D001089 | Arabinose |
| ID | Term |
|---|---|
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
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| Active comparator: 4% D-xylose | Dietary Supplement |
|
| Active comparator: 8% D-xylose | Dietary Supplement |
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| Active comparator: 8% L-arabinose | Dietary Supplement |
|