The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man

The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man

The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.

Based on previous scientific results we hypotesize, that pentoses decreases the demand for insulin in metabolizing a given dose of sucrose.

Inclusion Criteria:

• healthy males
• BMI between 18.4-25 kg/m2
• age between 18 and 30

Exclusion Criteria:

• donation of blood 3 months before or during the study
• gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease (HIV or hepatitis)
• smoking
• consumption of more than 21 alcoholic drinks/week
• elite athletes
• on medication