Dose Finding Study In Subjects With Crow's Feet

Dose Finding Study of Botulinum Neurotoxin Type A In Subjects With Crow's Feet (Lateral Canthal Lines)

The purpose of this study is to establish the therapeutic range of ANT-1401 in the treatment of Crow's Feet.

Inclusion Criteria:

• 30 - 60 years of age
• mild to moderate Crow's Feet wrinkles at rest
• moderate to severe Crow's Feet wrinkles on contraction
• willingness to refrain from any product affecting skin remodeling
• female subjects must be not pregnant and non-lactating

Exclusion Criteria:

• history of peri-ocular surgery, brow lift or related procedures
• procedures affecting the lateral canthal region in the prior 12 months
• application of topical prescription medication to the treatment area
• female subjects who are pregnant or are nursing a child