Clinical Trial to Evaluate ANT-1401 in Crow's Feet

Clinical Trial to Evaluate ANT-1401 in Subjects With Lateral Canthal Lines

The purpose of this study is to confirm the effect of ANT-1401 in the treatment of Lateral Canthal Lines.

Inclusion Criteria:

• 30 - 60 years of age
• mild to moderate Crow's Feet wrinkles (IGA 1-2) at rest
• moderate to severe Crow's Feet (IGA 2-3) on contraction
• moderate to severe Crow's Feet (SSA 2-3) on contraction
• Have adequate vision to assess facial wrinkles in a mirror

Exclusion Criteria:

• botulinum toxin treatment in the prior 6 months
• history of periocular surgery, brow lift or related procedures
• soft tissue augmentation in the lateral canthal region in the prior 12 months
• dermabrasion or laser treatment in the periocular region in the last 6 months
• topical prescription-strength retinoids in the prior 3 months
• present or history of neuromuscular disease
• present or history of "dry eye"
• systemic aminoglycoside use in the week prior to treatment application