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The purpose of this study is to provide evidence of the safety, tolerance, and efficacy of ANT-1207 in the treatment of Crow's Feet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo Comparator | Placebo Comparator |
| |
| Dose 1 | Experimental | Dose 1 |
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| Dose 2 | Experimental | Dose 2 |
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| Dose 3 | Experimental | Dose 3 |
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| Dose 4 | Experimental | Dose 4 |
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| Dose 5 | Experimental | Dose 5 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ANT-1207 | Biological | The interventions differ by dose of investigational product applied. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy will be assessed by Investigator's Global Assessment Score | Wrinkle scale with definitions of severity | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Subject Self Assessment (SSA) scale | Change from Baseline in the Subject Self Assessment scale | 2 Weeks |
| Investigator Global Assessment scale | Change from Baseline in wrinkle scale assessment at all other timepoints |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Total Skin & Beauty Dermatology Center | Birmingham | Alabama | 35205 | United States | ||
| Baumann Cosmetic & Research Institute |
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| ID | Term |
|---|---|
| D019274 | Botulinum Toxins, Type A |
| ID | Term |
|---|---|
| D001905 | Botulinum Toxins |
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
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|
| Botulinum Toxin, Type A | Biological | The interventions differ by dose of investigational product applied. |
|
| Botulinum Toxin Type A | Biological | The interventions differ by dose of investigational product applied. |
|
| Week 1, 2, 4, 8, 12 |
| Miami Beach |
| Florida |
| 33140 |
| United States |
| Palm Beach Esthetic Dermatology and Laser Center | West Palm Beach | Florida | 33401 | United States |
| William Coleman III, MD, APMC | Metairie | Louisiana | 70006 | United States |
| Gramercy Park Dermatology | New York | New York | 10010 | United States |
| Cary Skin Care | Cary | North Carolina | 27519 | United States |
| D006867 |
| Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D001426 | Bacterial Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |