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| ID | Type | Description | Link |
|---|---|---|---|
| R01MH077178 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
| University of Denver | OTHER |
| Rutgers University | OTHER |
| University of Illinois at Urbana-Champaign |
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Investigators will combine risk factor research and evidence-based prevention programs, to advance knowledge on personalized approaches to prevention that may be able to better "bend trajectories" of depression that surge throughout adolescence.
Investigators will innovatively combine risk factor research and evidence-based prevention programs, to advance knowledge on personalized approaches to prevention that may be able to better "bend trajectories" of depression that surge throughout adolescence. A randomized controlled trial will examine the benefits of matching youth to two depression prevention programs of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) and Coping with Stress (CWS) for the prevention of depression in adolescents. These two programs are designed to address distinct risk factors for depression - CWS addresses cognitive risks and IPT-AST addresses interpersonal risks. A total of 210 participants across two sites, University of Denver and Rutgers University, will be stratified on cognitive and interpersonal risk and randomized to the two conditions. The goals of the study are to (1) demonstrate that prevention programs can modify depression trajectories among youth by examining within person changes in trajectories over time (three years before and three years after the prevention programs) and by comparing trajectories of prevention youth with changes in same aged cohorts; (2) evaluate a personalized prevention approach to bending depression trajectories by matching and mismatching youth to either CWS or IPT-AST based on individual risk profiles; (3) examine mechanisms of bending depression trajectories and test whether the prevention programs operate via their hypothesized processes; and (4) explore how genetic susceptibility, emotion regulation, and temperament may affect individual response to IPT-AST and CWS. By implementing evidence-based prevention programs after 3-years of prospective naturalistic data collection, this study will contribute essential data on personalized medicine and altering developmental trajectories of first-onset depression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interpersonal Psychotherapy- Adolescent Skills Training | Experimental | Interpersonal Psychotherapy- Adolescent Skills Training |
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| Coping with Stress | Experimental | Coping with Stress |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interpersonal Psychotherapy- Adolescent Skills Training | Behavioral | A group prevention program that includes a 60-minute pre-group session, 8 weekly 90-minute group sessions, a 60-minute mid-group session, and 3 60-minute booster sessions. IPT-AST focuses on psychoeducation and interpersonal skill-building to decrease interpersonal conflict and increase interpersonal support and competence. |
| Measure | Description | Time Frame |
|---|---|---|
| Presence of a Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL) | Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation. | Post intervention (approximately 3 months post baseline) |
| Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL) | Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation. | 6-months post-intervention |
| Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL) | Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation. | 12-months post-intervention |
| Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL) | Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation. | 18-months post-intervention |
| Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL) | Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation. | 24-months post-intervention |
| Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL) |
| Measure | Description | Time Frame |
|---|---|---|
| Children's Global Assessment Scale (CGAS) | Assesses global functioning | Post Intervention (approximately 3 months following baseline) |
| Children's Global Assessment Scale (CGAS) | Assesses global functioning |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jami F Young, Ph.D. | Children's Hospital of Philadelphia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Denver | Denver | Colorado | 80208 | United States | ||
| University of Illinois Urbana Champaign |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38635190 | Derived | Jones JD, Schwartz KTG, Davis M, Gallop R, Hankin BL, Young JF. Cognitive and interpersonal moderators of two evidence-based depression prevention programs. J Consult Clin Psychol. 2024 Jul;92(7):432-444. doi: 10.1037/ccp0000886. Epub 2024 Apr 18. | |
| 33189876 | Derived | Young JF, Jones JD, Gallop R, Benas JS, Schueler CM, Garber J, Hankin BL. Personalized Depression Prevention: A Randomized Controlled Trial to Optimize Effects Through Risk-Informed Personalization. J Am Acad Child Adolesc Psychiatry. 2021 Sep;60(9):1116-1126.e1. doi: 10.1016/j.jaac.2020.11.004. Epub 2020 Nov 13. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Apr 18, 2017 | Mar 2, 2021 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D000097813 | Coping Skills |
| ID | Term |
|---|---|
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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| OTHER |
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| Coping with Stress | Behavioral | A group prevention program that consists of 8 acute 90-minute group sessions, 2 parent group sessions, and 3 continuation sessions lasting 60 minutes each. Participants are taught to apply cognitive techniques to their personal thoughts, with the goal of generating effective counterarguments to unrealistic negative beliefs. |
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Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation. |
| 30-months post-intervention |
| Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL) | Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation. | 36-months post-intervention |
| Children's Depression Inventory (CDI) | Self-reported depression scores | Post intervention (approximately 3 months after baseline) |
| Children's Depression Inventory (CDI) | Self-reported depression scores | 6-months post-intervention |
| Children's Depression Inventory (CDI) | Self-reported depression scores | 12-months post-intervention |
| Children's Depression Inventory (CDI) | Self-reported depression scores | 18-months post-intervention |
| Children's Depression Inventory (CDI) | Self-reported depression scores | 24-months post-intervention |
| Children's Depression Inventory (CDI) | Self-reported depression scores | 30-months post-intervention |
| Children's Depression Inventory (CDI) | Self-reported depression scores | 36-months post-intervention |
| 6-months followup |
| Children's Global Assessment Scale (CGAS) | Assesses global functioning | 12-months followup |
| Children's Global Assessment Scale (CGAS) | Assesses global functioning | 18-months followup |
| Children's Global Assessment Scale (CGAS) | Assesses global functioning | 24-months followup |
| Children's Global Assessment Scale (CGAS) | Assesses global functioning | 30-months followup |
| Children's Global Assessment Scale (CGAS) | Assesses global functioning | 36-months followup |
| Champaign |
| Illinois |
| 61820 |
| United States |
| Rutgers University | Piscataway | New Jersey | 08854 | United States |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19146 | United States |