Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy

Cerebrovascular Autoregulation in Patients With Severe Sepsis and Septic Shock, Influence of Renal Replacement Therapy

The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation.

Hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.

Inclusion Criteria:

• severe sepsis or septic shock
• adult patients
• possibility of transcranial Doppler ultrasound

Exclusion Criteria:

• traumatic brain injury
• known cerebrovascular diseases
• Infection of the brain
• chronic renal failure
• pregnancy