Improvement of Cerebrovascular Autoregulation in Patients With Septic Shock Due to Cytokine Elimination

Verbesserung Einer gestörten zerebrovaskulären Autoregulation Bei Patienten im Septischen Schock Durch Extrakorporale Reduktion Von Entzündungsmediatoren

The trial investigates the effect of cytokine elimination in patients with septic schock and acute renal failure with need for renal replacement therapy on the integrity of cerebrovascular autoregulation. Patients with inclusion criteria were randomly assign in either use of CytoSorb filter integrated in renal replacement therapy versus non additional filter an renal replacement therapy alone. Cerebrovascular autoregulation will be measured with transcranial Doppler ultrasound and correlation with arterial blood pressure.

Inclusion Criteria:

• septic shock
• acute renal failure with need for renal replacement therapy

Exclusion Criteria:

• pregnancy
• nursing
• impossibility to do transcranial Doppler ultrasound