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The aim of the study was to investigate whether CVVH, in comparison to intermittent haemodialysis (IHD), is able to improve regional perfusion in septic shock patients studied by muscle microdialysis
A prospective, randomized, clinical study ,including septic shock patients with acute renal failure, aged over 16 years. Patients were randomized to receive either CVVH or IHD for renal replacement therapy. Intermittent haemodialysis was carried out during the first 4 h at day 1 and day 2 of the study period. Systemic haemodynamics and interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline, 6, 12,18 and 24 hours after initiation of renal replacement by using muscle microdialysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CVVHF | Experimental | CVVHF for 48 h interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline, 6, 12,18 and 24 hours after initiation of renal replacement by using muscle microdialysis. |
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| IHD for 4 hours | Active Comparator | Intermittent haemodialysis was carried out during the first 4 h at day 1 and day 2 of the study period. Interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline, 6, 12,18 and 24 hours after initiation of renal replacement by using muscle microdialysis. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| muscle microdialysis | Device | Systemic haemodynamics and interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline, 6, 12,18 and 24 hours after initiation of renal replacement by using muscle microdialysis. |
| Measure | Description | Time Frame |
|---|---|---|
| changes in the concentration of glucose (mmol/l) in the extracellular fluid of the skeletal muscle using a microdialysis probe inserted into the quadriceps femoris muscle. | at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement | |
| changes in the concentration of lactate (mmol/l) in the extracellular fluid of the skeletal muscle using a microdialysis probe inserted into the quadriceps femoris muscle | at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement | |
| changes in the concentration of pyruvate (µmol/l) in the extracellular fluid of the skeletal muscle using a microdialysis probe inserted into the quadriceps femoris muscle | at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement | |
| changes in the concentration of glycerol (µmol/l) in the extracellular fluid of the skeletal muscle using a microdialysis probe inserted into the quadriceps femoris muscle | at baseline, 6, 12,18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement |
| Measure | Description | Time Frame |
|---|---|---|
| changes in mean arterial blood pressure | at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement | |
| changes in heart rate | at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| zied hajjej | Contact | 20358907 | 00216 | hajjej_zied@hotmail.com |
| mustapha ferjani | Contact | 98329256 | 00216 | mustapha.ferjani@planet.tn |
| Name | Affiliation | Role |
|---|---|---|
| mustapha ferhjani | Department of C ritical C are Medicine and Anesthesiology, Military Hospital of Tunis, Tunisia, Tunis, Tunisia | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Military Hopital of Tunis | Recruiting | Tunis | 1008 | Tunisia |
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| ID | Term |
|---|---|
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
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| changes in vasopressor support doses | at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |