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| Name | Class |
|---|---|
| Johns Hopkins University | OTHER |
| Tropical Diseases Research Centre, Zambia | OTHER_GOV |
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The purpose of the study is to determine whether daily consumption of beta-carotene biofortified maize will increase breast milk retinol concentration in lactating Zambian women.
Lactating women were randomly assigned to one of three intervention groups to receive 6d/wk for 3 wk either 1) provitamin A biofortified orange maize and a corn oil capsule, 2) white maize and a vitamin A capsule, or 3) white maize and a corn oil capsule. The 'orange maize' and 'vitamin A' groups received ~600 ug RAE/d as provitamin A biofortified maize or retinyl palmitate, respectively. The 'white maize' group was a negative control group that did not receive any supplemental vitamin A.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| white maize | Placebo Comparator | white maize and a corn oil capsule |
|
| orange maize | Experimental | orange maize and a corn oil capsule |
|
| vitamin A | Active Comparator | white maize and a vitamin A capsule |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| white maize and a corn oil capsule | Other | ~ 0 ug RAE/d |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Breast milk retinol concentration | Breast milk retinol concentration will be measured before and after 3 wk of consumption of orange maize (6 d/wk) | After 3 weeks of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Breastmilk beta-carotene concentration | Breastmilk beta-carotene concentration will be measured before and after 3 wk of consumption of orange maize (6d/wk) | After 3 wk of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma retinol concentration | Plasma retinol concentration will be measured before and after 3 wk of consumption of orange maize (6d/wk) | After 3 wk of intervention |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marjorie Haskell, PhD | University of California, Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Human Nutrition | Mkushi | Mkushi District | Zambia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27466608 | Derived | Palmer AC, Chileshe J, Hall AG, Barffour MA, Molobeka N, West KP Jr, Haskell MJ. Short-Term Daily Consumption of Provitamin A Carotenoid-Biofortified Maize Has Limited Impact on Breast Milk Retinol Concentrations in Zambian Women Enrolled in a Randomized Controlled Feeding Trial. J Nutr. 2016 Sep;146(9):1783-92. doi: 10.3945/jn.116.233700. Epub 2016 Jul 27. |
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| ID | Term |
|---|---|
| D014802 | Vitamin A Deficiency |
| D002145 | Callosities |
| ID | Term |
|---|---|
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D014801 | Vitamin A |
| C014794 | retinol palmitate |
| ID | Term |
|---|---|
| D012176 | Retinoids |
| D002338 | Carotenoids |
| D011090 | Polyenes |
| D000475 | Alkenes |
| D006839 |
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| orange maize and a corn oil capsule |
| Other |
~600 ug RAE/d |
|
|
| white maize and a vitamin A capsule | Other | 600 ug RAE/d |
|
|
| D009750 |
| Nutritional and Metabolic Diseases |
| D007642 | Keratosis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D053138 | Cyclohexenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D013729 | Terpenes |
| D004224 | Diterpenes |
| D010860 | Pigments, Biological |
| D001685 | Biological Factors |