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Determination of liver stores of vitamin A will be determined before and after consumption of high pro-vitamin A orange maize, compared to low provitamin A white maize.
This study will determine the change in total body stores of vitamin A in response to feeding orange maize for 90 days. This will be compared to two other groups of children that are fed white maize, one of which will get a vitamin A supplement at the estimated average requirement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Orange maize | Experimental | Children were fed orange maize and the intervention name was "orange" |
|
| Blue vitamin A group | Active Comparator | Received vitamin A in the form of retinyl palmitate in oil at the estimated average requirment. |
|
| White | Placebo Comparator | Received oil only at the same volume as the vitamin A group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Orange maize feeding | Other | This group was fed orange maize. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Vitamin A status changes | Vitamin A status is measured before and after the intervention. | After the intervention, which is approximately 3 months. |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32492125 | Derived | Sheftel J, Valentine AR, Hull AK, Fadjarwati T, Gannon BM, Davis CR, Tanumihardjo SA. Findings in 3 clinical trials challenge the accuracy of the Institute of Medicine's estimated average requirements for vitamin A in children and women. Am J Clin Nutr. 2021 May 8;113(5):1322-1331. doi: 10.1093/ajcn/nqaa132. | |
| 31254130 | Derived |
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| ID | Term |
|---|---|
| D002145 | Callosities |
| ID | Term |
|---|---|
| D007642 | Keratosis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| Vitamin A supplement |
| Other |
This group received a dose of vitamin A at the estimated average requirement each feeding day of the intervention. |
|
| Oil only | Other | This group received a small amount of plain oil without vitamin A. |
|
| Tanumihardjo SA, Gannon BM, Kaliwile C, Chileshe J, Binkley NC. Restricting vitamin A intake increases bone formation in Zambian children with high liver stores of vitamin. Arch Osteoporos. 2019 Jun 28;14(1):72. doi: 10.1007/s11657-019-0617-y. |
| 29528727 | Derived | Titcomb TJ, Schmaelzle ST, Nuss ET, Gregory JF 3rd, Tanumihardjo SA. Suboptimal Vitamin B Intakes of Zambian Preschool Children: Evaluation of 24-Hour Dietary Recalls. Food Nutr Bull. 2018 Jun;39(2):281-289. doi: 10.1177/0379572118760373. Epub 2018 Mar 11. |
| 26447158 | Derived | Suri DJ, Tanumihardjo JP, Gannon BM, Pinkaew S, Kaliwile C, Chileshe J, Tanumihardjo SA. Serum retinol concentrations demonstrate high specificity after correcting for inflammation but questionable sensitivity compared with liver stores calculated from isotope dilution in determining vitamin A deficiency in Thai and Zambian children. Am J Clin Nutr. 2015 Nov;102(5):1259-65. doi: 10.3945/ajcn.115.113050. Epub 2015 Oct 7. |
| 26178727 | Derived | Mondloch S, Gannon BM, Davis CR, Chileshe J, Kaliwile C, Masi C, Rios-Avila L, Gregory JF 3rd, Tanumihardjo SA. High provitamin A carotenoid serum concentrations, elevated retinyl esters, and saturated retinol-binding protein in Zambian preschool children are consistent with the presence of high liver vitamin A stores. Am J Clin Nutr. 2015 Aug;102(2):497-504. doi: 10.3945/ajcn.115.112383. Epub 2015 Jul 15. |
| 25411289 | Derived | Gannon B, Kaliwile C, Arscott SA, Schmaelzle S, Chileshe J, Kalungwana N, Mosonda M, Pixley K, Masi C, Tanumihardjo SA. Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: a community-based, randomized placebo-controlled trial. Am J Clin Nutr. 2014 Dec;100(6):1541-50. doi: 10.3945/ajcn.114.087379. Epub 2014 Oct 8. |