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| Name | Class |
|---|---|
| University of California, Davis | OTHER |
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The study will assess the relative bioavailability and bioefficacy of cryptoxanthin (CX) and beta-carotene (BC) from food sources for increasing breast milk carotenoid and retinol concentrations in lactating Bangladeshi women.
The specific aim is to compare the effects of orange-fleshed sweet potatoes and tangerines compared to white-fleshed sweet potatoes and vitamin A as retinyl palmitate on blood and breast milk cryptoxanthin (CX), beta-carotene (BC), and vitamin A (VA) concentrations by randomly assigning lactating Bangladeshi women to one of four treatment groups for 6 days/week for 3 weeks.
The investigators will also compare the relative vitamin A (VA) value of BC and CX from food sources by comparing the mean change in breast milk retinol concentrations of the groups that receive tangerines (CX) or orange-fleshed sweet potatoes (BC) with the mean change in breast milk retinol of the group that receives retinyl palmitate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0 mg retinol | Placebo Comparator | 0 mg retinol activity equivalents (RAE) as white-fleshed sweet potatoes and a corn oil capsule |
|
| 12 mg BC | Experimental | 12 mg of BC as orange-fleshed sweet potatoes and a corn oil capsule. |
|
| 6 mg of CX | Experimental | 6 mg of CX as tangerines and a corn oil capsule |
|
| 1.0 mg RAE | Experimental | 1.0 mg RAE vitamin A as retinyl palmitate in corn oil, and white-fleshed sweet potatoes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0 mg retinol activity equivalents | Other | 0 mg retinol activity equivalents (RAE) as white-fleshed sweet potatoes and a corn oil capsule |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in carotenoids in serum and breast milk | We will measure serum and breast milk beta-carotene, beta-cryptoxanthin, other carotenoids, and vitamins A and E. | 1 and 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Dark adaptation | Dark adaptation will be measured by the pupillary threshold (PT) test on the first and 3rd weeks of the study. | 1 and 3 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Betty J Burri, PhD | WHNRC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| International Centre for Diarrhoeal Disease Research | Dhaka | Bangladesh |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24004891 | Derived | Turner T, Burri BJ, Jamil KM, Jamil M. The effects of daily consumption of beta-cryptoxanthin-rich tangerines and beta-carotene-rich sweet potatoes on vitamin A and carotenoid concentrations in plasma and breast milk of Bangladeshi women with low vitamin A status in a randomized controlled trial. Am J Clin Nutr. 2013 Nov;98(5):1200-8. doi: 10.3945/ajcn.113.058180. Epub 2013 Sep 4. |
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| ID | Term |
|---|---|
| D014802 | Vitamin A Deficiency |
| D001942 | Breast Feeding |
| ID | Term |
|---|---|
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
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| 12 mg of BC | Other | 12 mg of BC as orange-fleshed sweet potatoes and a corn oil capsule |
|
| 6 mg of CX | Other | 6 mg of CX as tangerines and a corn oil capsule |
|
| 1.0 mg RAE | Other | 1.0 mg RAE vitamin A as retinyl palmitate in corn oil, and white-fleshed sweet potatoes |
|
| D009750 |
| Nutritional and Metabolic Diseases |
| D005247 | Feeding Behavior |
| D001519 | Behavior |