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| Name | Class |
|---|---|
| Korea Institute of Science and Technology | OTHER |
The overall aim of the proposed study is to determine optimal parameter of focal muscle vibration for improving spasticity and identify neurophysiological mechanism in healthy subjects.
In investigation I-1, subjects will undergo focal muscle vibration with 40, 80, 120 Hz frequency at the medial gastrocnemius muscles (mGCM). As a surrogate maker of spasticity, H-reflex and compound motor action potential (CMAP) of the tibial nerve at mGCM will be recorded pre, during, and post vibration.
In investigation I-2, subjects will undergo focal muscle vibration with 0.1, 0.3, 0.5 mm amplitude at mGCM. H-reflex and CMAP of the tibial nerve at mGCM will be recorded pre, during, and post vibration.
In investigation II, subjects will undergo focal muscle vibration with predetermined parameters by the investigation I at mGCM. H-reflex and CMAP of the tibial nerve and motor evoked potential at mGCM will be recorded pre, during, and post vibration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Focal muscle vibration | Experimental | Focal muscular vibration will be applied at mGCM of each subject for 10 minutes in each session. Frequency: 40, 80, 120 Hz Amplitude: 0.1, 0.3, 0.5 mm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Focal muscular vibration | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| H/M ratio | The ratio of maximal H-reflex amplitude (mV) to CMAP amplitude (mV) recorded at mGCM | baseline, 1, 5 and 10 minutes during vibration, and 1 and 5 minutes after vibration |
| Measure | Description | Time Frame |
|---|---|---|
| H amplitude | maximal H-reflex amplitude (mV) recorded at mGCM | baseline, 1, 5 and 10 minutes during vibration, and 1 and 5 minutes after vibration |
| M amplitude | CMAP amplitude (mV) recorded at mGCM |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea |
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| ID | Term |
|---|---|
| D009128 | Muscle Spasticity |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009122 | Muscle Hypertonia |
| D020879 | Neuromuscular Manifestations |
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| baseline, 1, 5 and 10 minutes during vibration, and 1 and 5 minutes after vibration |
| motor evoked potential (MEP) amplitude | Transcranial magnetic stimulation on the contralateral leg motor cortex is used to measure MEP at mGCM. | baseline, 10 minutes during vibration, and 5 minutes after vibration |
| Resting motor threshold (RMT) | Resting motor threshold (%) is defined as the minimal intensity of TMS capable of inducing MEPs greater than 100μV peak-to-peak amplitude in at least 3 of 5 trials. | baseline, 10 minutes during vibration, and 5 minutes after vibration |
| Short interval intracortical inhibition | Short interval intracortical inhibition is recorded by using conditioning stimulus of 90% RMT and test stimulus of 120% RMT with 1ms interval. | baseline, 10 minutes during vibration, and 5 minutes after vibration |
| Intracortical facilitation | Intracortical facilitation is recorded by using conditioning stimulus of 90% RMT and test stimulus of 120% RMT with 10ms interval. | baseline, 10 minutes during vibration, and 5 minutes after vibration |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |