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Randomised training intervention.
Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell
Sarcopenia
Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible.
Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endurance and Resistance Training | Experimental | Endurance and resistance exercise |
|
| Resistance Training | Experimental | resistance exercise (12wk) |
|
| Resistance and resistance Training | Experimental | resistance exercise (24 wk) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes | Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes | participants will be followed for the duration of training period, an expected average of 7 months |
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Inclusion criteria: -male
Exclusion criteria: -female
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| Name | Affiliation | Role |
|---|---|---|
| Hans H Jung, Prof MD | University Hospital Zurich, Division of Neurology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich, Division of Neurology | Zurich | Canton of Zurich | 8091 | Switzerland |
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