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| Name | Class |
|---|---|
| Kaiser Franz Josef Hospital | OTHER |
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The aim of this randomized, observer-blind, controlled intervention study with parallel groups is to study the effect of strength training (2x/week for 6 months) with and without additional dietary supplementation (protein-enriched) on muscle strength, function and mass, oxidative stress parameters and the immune system in elderly institutionalized persons.
The participants (n = 120) are recruited from Viennese senior residencies (Kuratorium Wiener Pensionistenwohnheime). After a pre-participation screening participants will be distributed randomly but stratified by sex and age to one of the 3 intervention groups (cognitive training, strength training, strength training + supplement).
Study participants are eligible if they are male or female with an age over 65 years and if their cognitive status as well as their physical fitness level allows to participate at the strength training sessions. Exclusion criteria comprise chronic diseases which contraindicate the medical training therapy, serious cardiovascular disease, diabetic retinopathy and manifest osteoporosis, medication with anticoagulants or cortisone drugs and also regular strength training during the last six months.
Primary outcome measure is the change in isokinetic torque of knee extensors. Secondary outcome measures comprise anthropometric data, functional performance tests, immunological and oxidative stress parameters. The change in muscle signaling pathways will be assessed from muscle biopsies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive Training | Sham Comparator | Cognitive Training (riddles, skill games, ...) is performed twice a week in small groups |
|
| Strength Training | Experimental | Progressive strength training is applied, meaning that the intensity is adjusted continuously in order to obtain a sufficient training stimulus. Exercises are chosen to involve the major muscle groups and are performed by using the own body weight or elastic bands. |
|
| Strength Training and Supplement | Experimental | In addition to strength training as described above, participants receive a water-soluble dietary supplement 9x/week (FortiFit, Nutricia) consisting of 20.7 g of protein (56 En%, 19.7 g whey protein, 3 g leucine,> 10 g essential amino acids), 9.3 g carbohydrates (25 En%, 0.8 BE), 3.0 g fat (18 En%), 1.2 g fiber (2 En%), 800 IU (20μg) of vitamin D, 250mg calcium, vitamins B6 and B12, folic acid and magnesium. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Training | Behavioral |
| ||
| Strength Training |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in isokinetic torque of knee extensors | baseline and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in 6min walking test | baseline and 6 months | |
| change from baseline in handgrip strength | baseline and 6 months | |
| change from baseline in single leg balance stand |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in isokinetic torque of knee extensors at 12 months | baseline and 12 months | |
| change from baseline in isokinetic torque of knee extensors at 18 months | baseline and 18 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Quittan, Prim. Univ.Prof. Dr. | Contact | +43160191 | 3401 | michael.quittan@wienkav.at |
| Barbara Wessner, Ass.-Prof. DI Dr. | Contact | +4314277 | 28772 | barbara.wessner@univie.ac.at |
| Name | Affiliation | Role |
|---|---|---|
| Barbara Wessner, Ass.-Prof. DI Dr. | University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Vienna, Centre of Sports Science and University Sports | Recruiting | Vienna | State of Vienna | 1150 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29698742 | Derived | Franzke B, Schober-Halper B, Hofmann M, Oesen S, Tosevska A, Henriksen T, Poulsen HE, Strasser EM, Wessner B, Wagner KH. Age and the effect of exercise, nutrition and cognitive training on oxidative stress - The Vienna Active Aging Study (VAAS), a randomized controlled trial. Free Radic Biol Med. 2018 Jun;121:69-77. doi: 10.1016/j.freeradbiomed.2018.04.565. Epub 2018 Apr 24. | |
| 27905522 |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000091942 | Cognitive Training |
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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|
| FortiFit | Dietary Supplement |
|
| baseline and 6 months |
| change from baseline in lean body mass | baseline and 6 months |
| change from baseline in muscular myostatin expression | baseline and 6 months |
| change from baseline in DNA strand breaks | baseline and 6 months |
| change from baseline in high-sensitive C reactive protein | baseline and 6 months |
| Derived |
| Tosevska A, Franzke B, Hofmann M, Vierheilig I, Schober-Halper B, Oesen S, Neubauer O, Wessner B, Wagner KH. Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial. Sci Rep. 2016 Dec 1;6:38084. doi: 10.1038/srep38084. |
| 26515246 | Derived | Grimpampi E, Oesen S, Halper B, Hofmann M, Wessner B, Mazza C. Reliability of gait variability assessment in older individuals during a six-minute walk test. J Biomech. 2015 Nov 26;48(15):4185-4189. doi: 10.1016/j.jbiomech.2015.10.008. Epub 2015 Oct 20. |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D005081 | Exercise Therapy |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |