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Anesthesia induction and tracheal intubation can be performed with and without neuromuscular blocking agents (NMBAs). Tracheal intubation can be performed with sevoflurane instead of NMBAs; intubating conditions are similar and the incidence of vocal cord injuries are similar, too.
We perform tracheal intubation with propofol, remifentanil and sevoflurane; sevoflurane is administered with three dosages. During tracheal intubation intubating conditions are noted. After surgery, all patients are examined by video laryngoscopy; moreover all patients are asked for hoarseness and sore throat.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sevoflurane 1,0 | Active Comparator | sevoflurane 1,0: sevoflurane is administered with a concentration of 1,0 MAC |
|
| sevoflurane 1,2 | Active Comparator | sevoflurane 1,2: sevoflurane is administered with a concentration of 1,2 MAC |
|
| sevoflurane 1,4 | Active Comparator | sevoflurane 1,4: sevoflurane is administered with a concentration of 1,4 MAC |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sevoflurane 1,0 | Drug | anesthesia induction with propofol, remifentanil, and sevoflurane 1,0 MAC; afterwards tracheal intubation |
|
| Measure | Description | Time Frame |
|---|---|---|
| incidence of vocal cord injuries | 24 hours after tracheal intubation |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of hoarseness | 24, 48, and 72 hours after tracheal intubation | |
| incidence of soar throat | 24, 48, and 72 hours after tracheal intubation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thomas Mencke, Dr. | Dep. of Anesthesia and Intensive Care Medicine, University of Rostock, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesia and Intensive Care Medicine, University of Rostock | Rostock | Mecklenburg-Vorpommern | 18057 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28449630 | Derived | Ovari A, Bicker I, Machmueller S, Schuldt T, Sauer M, Soltesz S, Noeldge-Schomburg G, Mlynski R, Mencke T. Sevoflurane at 1.0 MAC together with remifentanil and propofol produces clinically acceptable intubation conditions at the vocal cords: A prospective randomized study. J Int Med Res. 2017 Jun;45(3):1098-1108. doi: 10.1177/0300060517701355. Epub 2017 Apr 28. |
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| sevoflurane 1,2 | Drug | anesthesia induction with propofol, remifentanil, and sevoflurane 1,2 MAC; afterwards tracheal intubation |
|
|
| sevoflurane 1,4 | Drug | anesthesia induction with propofol, remifentanil, and sevoflurane 1,4 MAC; afterwards tracheal intubation |
|
|
| ID | Term |
|---|---|
| D006685 | Hoarseness |
| D010612 | Pharyngitis |
| ID | Term |
|---|---|
| D014832 | Voice Disorders |
| D007818 | Laryngeal Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D010038 | Otorhinolaryngologic Diseases |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012818 | Signs and Symptoms, Respiratory |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
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