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| Name | Class |
|---|---|
| Fondation avenir | UNKNOWN |
| laboratoire Genzyme | UNKNOWN |
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The purpose of the study is to investigate the contribution of molecular cytological analysis (CMA) and shear wave elastography ShearWave (SWE) in the diagnosis of nodules with indeterminate cytology (IC)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| aspiration for Molecular Cytogenetic Analysis. | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| aspiration in thyroid node for Molecular Cytogenetic Analysis. | Procedure |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the diagnostic performance of the AMC and SWE elastography | Evaluate the diagnostic performance of the AMC and SWE elastography in patients with a thyroid nodule CI taking as reference the histology of the nodule. | at inclusion, before surgery |
| Measure | Description | Time Frame |
|---|---|---|
| evaluate the diagnostic performance of elastography SWE | For elastography SWE validate decision thresholds for the parameters of elasticity of thyroid nodules, and evaluate the diagnostic performance of elastography SWE combined with those of the standard ultrasound. | at inclusion, before surgery |
| Establish a combined diagnostic score results of elastography |
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Inclusion Criteria:
Age ≥ 18 years
Patients with thyroid nodules ≥ 15 mm with an indeterminate cytology (IC) older than 6 months, for which a surgical indication was raised
Confirmation of indeterminate cytology (IC) replay centralized
Patient affiliated to a social security scheme
Informed consent and signed
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre François BACLESSE | Caen | Calvados | 14000 | France | ||
| CHU |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32638211 | Derived | Bardet S, Goardon N, Lequesne J, Vaur D, Ciappuccini R, Leconte A, Monpeyssen H, Saguet-Rysanek V, Clarisse B, Lasne-Cardon A, Menegaux F, Leenhardt L, Buffet C. Diagnostic and prognostic value of a 7-panel mutation testing in thyroid nodules with indeterminate cytology: the SWEETMAC study. Endocrine. 2021 Feb;71(2):407-417. doi: 10.1007/s12020-020-02411-4. Epub 2020 Jul 7. |
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Establish a combined diagnostic score results of elastography, the standard ultrasound and molecular analysis |
| at inclusion, before surgery |
| Caen |
| Calvados |
| 14000 |
| France |
| Hôpital Américain de Paris | Neuilly-sur-Seine | France |
| Hôpital Pitié-salpétrière | Paris | 75 000 | France |
| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
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