Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In order to investigate if individuals, carrying genetic variants predisposing to obesity, respond differently to visual presented food images than non-carriers the investigators aim to screen 500 people for a common risk variant in the FTO gene. From those 500 screened 40 subjects, 20 homozygous for the risk allele and 20 homozygous for a non risk allele will be selected for the second step in the study. This part involves the fMRI technique to visualize the brain response, focus on reward system activation, when food images are visually presented in the scanner. Factors regarding eating behavior, sleep, physical exercise and relation to food are investigated in the first part of the study as well as clinical parameters such as BMI.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Risk allele carriers | Experimental | Individuals homozygous for the risk allele (A/A) The interventions administrated to this group: 'Blood sampling for genetic analyse', 'Stroop test', 'fMRI' |
|
| Non risk allele carriers | Experimental | Individuals homozygous for the non-risk allele (T/T) The interventions administrated to this group: 'Blood sampling for genetic analyse', 'Stroop test', 'fMRI' |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling for genetic analyse | Procedure | Blood sampling are performed at the initiation visit in order to screen for allele variants |
|
| Measure | Description | Time Frame |
|---|---|---|
| Genotyping for variants in the FTO gene associated with overweight and obesity | Blood sampling for genetic analyse is performed at the initiation visit |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christian Benedict, PhD | Contact | christian.benedict@neuro.uu.se |
| Name | Affiliation | Role |
|---|---|---|
| Christian Benedict, PhD | dep. Neuroscience, Uppsala University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uppsala University | Recruiting | Uppsala | Uppsala County | 752 72 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40759193 | Derived | Andreoli MF, De Francesco PN, Titova OE, Perello M, Schioth HB. Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status. Physiol Behav. 2025 Nov 1;301:115049. doi: 10.1016/j.physbeh.2025.115049. Epub 2025 Aug 7. | |
| 39140219 | Derived |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D009765 | Obesity |
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D057190 | Stroop Test |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Stroop test | Behavioral | Selective attention test where subjects, in one minute, names the ink color of several words without naming the word itself. |
|
| fMRI | Other | Functional Magnetic Resonance Imaging, performed to view brain activity |
|
| dep. Neuroscience, Uppsala University | Recruiting | Uppsala | Uppsala County | Sweden |
|
| Andreoli MF, Kruger AL, Sokolov AV, Rukh G, De Francesco PN, Perello M, Schioth HB. LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans. Diabetes Obes Metab. 2024 Oct;26(10):4734-4743. doi: 10.1111/dom.15850. Epub 2024 Aug 14. |
| 28194012 | Derived | Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schurmann A, Larsson EM, Rask-Andersen M, Benedict C, Schioth HB. A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels. Int J Obes (Lond). 2017 Jun;41(6):990-994. doi: 10.1038/ijo.2017.43. Epub 2017 Feb 14. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001522 | Behavior, Animal |
| D001519 | Behavior |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D009483 | Neuropsychological Tests |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |