Functional Magnetic Resonance Imaging (fMRI) Exploration of Neurocognitive Processes Involved in Food Addiction (FA) in Obese Patients: Towards New Phenotypic Markers for an Optimized Care Pathway

Functional Magnetic Resonance Imaging (fMRI) Exploration of Neurocognitive Processes Involved in Food Addiction (FA) in Obese Patients: Towards New Phenotypic Markers for an Optimized Care Pathway

Identification of the cerebral fMRI phenotype of obese patients with FA in cognitive task context based on food choice making

Obesity is a worldwide epidemic associated with many complications. The treatment of obesity is a failure if it does not take into account eating disorders. Among them, food addictions seem to be frequent among obese patients. Clinical diagnosis and therapeutic approaches depend on presence of these FA. Moreover, eating disorders are associated with visible brain abnormalities in fMRI but the cerebral fMRI phenotype of FA is not known.

Inclusion Criteria:

• female
• right-handed
• grade 1 and 2 obesity
• aged between 20 and 50
• no other addictions including smoking
• no contraindications to fMRI
• affiliated to French Social Security
• having given a written informed consent

Exclusion Criteria:

• abdominal circumference + upper limbs along the body > 200cm
• addiction to alcohol or other psychoactive substances
• daily smoker
• sleep Apnea Syndrome paired
• psychotic psychiatric disorders
• history of bariatric surgery
• medical care in the nutrition unit
• inability to comprehend or complete questionnaires
• pregnant or breastfeeding woman
• persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty.