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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A01269-44 | Other Identifier | N°ID-RCB |
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| Name | Class |
|---|---|
| Institut NuMeCan, INRAE 1341 | UNKNOWN |
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Identification of the cerebral fMRI phenotype of obese patients with FA in cognitive task context based on food choice making
Obesity is a worldwide epidemic associated with many complications. The treatment of obesity is a failure if it does not take into account eating disorders. Among them, food addictions seem to be frequent among obese patients. Clinical diagnosis and therapeutic approaches depend on presence of these FA. Moreover, eating disorders are associated with visible brain abnormalities in fMRI but the cerebral fMRI phenotype of FA is not known.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient with food addcitions | Experimental | Patients (20) will be selected from the Yale Food Addiction Scale (YFAS): a validated screening of FA questionnaire. Three clinical visits will be realized in less than two months |
|
| Patients without food addictions | Experimental | Patients (20) will be selected from the Yale Food Addiction Scale (YFAS): a validated screening of FA questionnaire. Three clinical visits will be realized in less than two months |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI | Device | Brain MRI |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Significant change in brain activity of the prefrontal cortex (area involved in the inhibitory control of food intake) measured by modification of BOLD (Blood-Oxygen-Level-Dependent) signal in fMRI during a cognitive task based on food choice making | Month 2 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David Val-Laillet, MSc, PhD, HDR | Institut NuMeCan, INRA 1341, INSERM 1241, Université de Rennes 1 | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Rennes | Rennes | 35033 | France |
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| Indirect calorimetry |
| Device |
Resting energy expenditure |
|
| Bioimpedance | Device | Measurement of body composition |
|
| Lipid profile, glucose, HBA1c, metabolomic analysis | Biological | Blood sample |
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| YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking) | Behavioral | Questionnaires to characterize eating habits and depression |
|
| ID | Term |
|---|---|
| D009765 | Obesity |
| D000073932 | Food Addiction |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D016739 | Behavior, Addictive |
| D003192 | Compulsive Behavior |
| D007175 | Impulsive Behavior |
| D001519 | Behavior |
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| D002153 | Calorimetry, Indirect |
| D005947 | Glucose |
| D014894 | Weights and Measures |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D002151 | Calorimetry |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
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