Cannabinoids and Cerebellar-Motor Functioning

Cannabinoids and Cerebellar-Motor Functioning

The purpose of this study is to characterize the dose-related effects of delta-9-tetrahydrocannabinol (∆9-THC) in healthy individuals on cerebellum-dependent motor functions.

The overall aim of the current proposal is to investigate whether acute, IV ∆9-THC administration mediates cerebellar versus forebrain-dependent associative learning in humans as assessed with eyeblink conditioning (EBC). In addition, a battery of motor function tests will also be administered (the CANTAB motor screening test, Grooved Pegboard Motor Task, paced finger tapping).

Inclusion Criteria:

• Must have used cannabis at least once in their lifetime
• No cannabis use in the past month
• Men and women aged 21 to 35 years (extremes included) on the day of the first dosing

Exclusion Criteria:

• Hearing deficits
• Psychiatric or mental disorders
• Hearing Deficits