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The purpose of this study is to characterize the dose-related effects of delta-9-tetrahydrocannabinol (∆9-THC) in healthy individuals on cerebellum-dependent motor functions.
The overall aim of the current proposal is to investigate whether acute, IV ∆9-THC administration mediates cerebellar versus forebrain-dependent associative learning in humans as assessed with eyeblink conditioning (EBC). In addition, a battery of motor function tests will also be administered (the CANTAB motor screening test, Grooved Pegboard Motor Task, paced finger tapping).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| THC | Active Comparator | Very low dose (0.0015 mg/kg = 0.21 mg in a 70 kg individual) THC, dissolved in alcohol. Administered intravenously over 10 minutes. Low dose (0.015 mg/kg = 1.05 mg in a 70 kg individual) THC, dissolved in alcohol. This dose is roughly equivalent to smoking approximately ¼ of a marijuana cigarette, or "joint". Administered intravenously over 10 minutes. Medium dose (0.03 mg/kg = 2.1 mg in a 70 kg individual) THC, dissolved in alcohol. This dose is roughly equivalent to smoking approximately ½ of a marijuana cigarette, or "joint". Administered intravenously over 10 minutes. |
|
| Placebo | Placebo Comparator | Control: small amount of alcohol intravenous (quarter teaspoon), with no THC over 10 minutes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| THC | Drug | Very low dose (0.0015 mg/kg = 0.21 mg in a 70 kg individual) THC, dissolved in alcohol. Administered intravenously over 10 minutes. Low Dose (0.015 mg/kg = 1.05 mg in a 70 kg individual) THC, dissolved in alcohol. This dose is roughly equivalent to smoking approximately ¼ of a marijuana cigarette, or "joint". Administered intravenously over 10 minutes. Medium dose (0.03 mg/kg = 2.1 mg in a 70 kg individual) THC, dissolved in alcohol. This dose is roughly equivalent to smoking approximately ½ of a marijuana cigarette, or "joint". Administered intravenously over 10 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebellum Dependent Associative Learning (% CRs) | % conditioned responses (CRs) will be measured | Measured +15 minutes after infusion |
| Cerebellum Dependent Associative Learning (CR Latency) | conditioned response (CR) Latency will be measured | Measured +15 minutes after infusion |
| Completion of the Grooved Pegboard Motor Task (Reaction Time/Accuracy) | Total time taken to complete the grooved pegboard tasks will be the dependent measure. | Measured +45 minutes after infusion |
| CANTAB Motor Screening Test (Reaction Time) | Using a touch screen, reaction time to touch a target will be the dependent measures. | Measured +45 minutes after infusion |
| CANTAB Motor Screening Test (Accuracy) | Using a touch screen, accuracy to touch a target will be the dependent measures. | Measured +45 minutes after infusion |
| Paced Finger Tapping (Correct Responses) | Using a button on a computer keyboard, correct responses will be measured. | Measured +45 minutes after infusion |
| Paced Finger Tapping (Reaction Time) | Using a button on a computer keyboard, reaction time and tapping variability will be measured. | Measured +45 minutes after infusion |
| Measure | Description | Time Frame |
|---|---|---|
| THC intoxication, as measured by the Visual Analog Scale (Total Score) | 0 being none; 100 being completely | Baseline; +45, +100, +240 minutes after infusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Connecticut Healthcare System | West Haven | Connecticut | 06516 | United States |
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| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| D011618 | Psychotic Disorders |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
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| ID | Term |
|---|---|
| D013759 | Dronabinol |
| ID | Term |
|---|---|
| D002186 | Cannabinoids |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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|
| Placebo | Drug | Control: small amount of alcohol intravenous (quarter teaspoon), with no THC over 10 minutes. |
|