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| ID | Type | Description | Link |
|---|---|---|---|
| R21DA056687 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The purpose of this research is to determine the extent to which oculomotor function accurately detects THC-impairment, if cannabis use experience impacts this detection threshold, and to examine how the oculomotor index corresponds to a measure of sustained attention. A double-blind, placebo-controlled, within-subjects crossover design will be used to examine the dose-effects of THC (0, 5mg, 30mg) on oculomotor performance tasks and a sustained attention task in frequent and infrequent cannabis users. Results from the study will advance the investigators' understanding of the effect of THC and cannabis use frequency on oculomotor function and sustained attention, and will directly inform the validity of the investigators' oculomotor platform for identifying acute THC- induced impairment in frequent and infrequent users.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0 mg THC | Placebo Comparator | Inhaled Cannabis - 0 mg THC |
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| 5 mg THC | Experimental | Inhaled cannabis - 5 mg THC |
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| 30 mg THC | Experimental | Inhaled cannabis - 30 mg THC |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cannabis | Drug | cannabis with 0, 5, or 30 mg THC will be inhaled via vaporization |
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| Measure | Description | Time Frame |
|---|---|---|
| Commission Errors | The Conners Continuous Performance Test (CPT) will be used to assess sustained attention. Commission errors is measured by calculating the number of trials participants incorrectly push the spacebar in the presence of "X" stimulus. | pre-administration, post-administration, 2, 4 hours |
| Omission Errors | The Conners Continuous Performance Test (CPT) will be used to assess sustained attention. Omission errors is measured by calculating the number of trials participants fail to push the spacebar in the presence of a letter that is not an "X" stimulus. | pre-administration, post-administration, 2, 4 hours |
| Reaction Time | The Conners Continuous Performance Test (CPT) will be used to assess sustained attention. Reaction time is measured by calculating the duration between the presentation of a letter other than "X", and the correct response of a spacebar push. | pre-administration, post-administration, 2, 4 hours |
| Reaction Time Standard Error | The Conners Continuous Performance Test (CPT) will be used to assess sustained attention. Reaction time standard error is measured by calculating the standard error of the mean of the reaction time. | pre-administration, post-administration, 2, 4 hours |
| Visuomotor Index | The visuomotor index score is calculated by mathematically integrating five measures of oculomotor fixation performance and two measures of accuracy into a single score during fixation and accuracy tasks, respectively. Test of visual fixation to measure microsaccades, spontaneous nystagmus, and gaze-evoked nystagmus. | pre-administration, post-administration, 2, 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Saccade Speed | Measures how quickly participants look back and forth between two spots as possible during the oculomotor task. | Pre-administration, post-administration, 2, 4 hours |
| Visually Guided Oculomotor Performance |
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Inclusion Criteria:
These criteria were selected to target individuals with low and high-frequency cannabis use in order to examine the direct effect of tolerance on study outcome measures.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dustin C Lee, PhD | Contact | 410-550-4035 | dlee214@jhmi.edu |
| Name | Affiliation | Role |
|---|---|---|
| Dustin C Lee, PhD | Johns Hopkins University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins Behavioral Pharmacology Research Unit | Baltimore | Maryland | 21224 | United States |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D019966 | Substance-Related Disorders |
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| ID | Term |
|---|---|
| C587251 | nabiximols |
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double-blind, placebo-controlled, within-subjects crossover design
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placebo controlled, double-blind
Measures how quickly and accurately participants move their eyes to a cue as soon as it appears on the oculomotor task.
| Pre-administration, post-administration, 2, 4 hours |
| Antisaccade | Measures voluntary eye movement in the direction opposite to the side in which a visual cue is presented. | Pre-administration, post-administration, 2, 4 hours |
| Memory-Guided | Measures how quickly gaze is shifted directly and accurately to a remembered cue position. | Pre-administration, post-administration, 2, 4 hours |
| D064419 | Chemically-Induced Disorders |