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The purpose of this study is to analyze the efficacy of MicroRNAs as biomarkers on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of this molecule with functional and laboratory tests.
The patients included in the study must at first sign the written consent. They shall be accompanied in the specialized outpatient clinics for Chagas disease - Hospital São Rafael - Centro de Biotecnologia e Terapia Celular. They will be submitted to several tests, including:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Chagas disease diagnosis | Diagnosis of Chagas disease in both forms: indeterminate and cardiac ones, with and without ventricular dysfunction. |
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| Measure | Description | Time Frame |
|---|---|---|
| Correlation of plasmatic levels of MicroRNAs with the percentage of heart fibrosis | Mensuration of heart fibrosis percentage with Magnetic Resonance Imaging | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of plasmatic levels of MicroRNAs with the functional cardiovascular capacity | Mensuration of the functional capacity with treadmill test. | One year |
| Correlation of plasmatic levels of MicroRNAs with the left ventricular function |
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Inclusion Criteria:
Exclusion Criteria:
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Tertiary Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Milena Botelho Pereira Soares, PhD | Hospital São Rafael | Principal Investigator |
| Ricardo Ribeiro dos Santos, MD | Hospital São Rafael | Study Director |
| Ticiana Ferreira Larocca, MD | Hospital São Rafael | Study Chair |
| Márcia Maria Noya Rabelo, MD | Hospital São Rafael | Study Chair |
| Luís Cláudio Lemos Correia, MD | Hospital São Rafael | Study Chair |
| Bruno Solano de Freitas Souza, MD | Hospital São Rafael | Study Chair |
| Carolina Thé Macedo, MD | Hospital São Rafael | Study Chair |
| Ana Luiza Dias Angelo, PhD | Hospital São Rafael | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital São Rafael | Salvador | Estado de Bahia | 41253-190 | Brazil |
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| ID | Term |
|---|---|
| D014355 | Chagas Disease |
| ID | Term |
|---|---|
| D014352 | Trypanosomiasis |
| D056986 | Euglenozoa Infections |
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
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Plasma, Serum, Whole Blood
Mensuration of the left ventricular function with echocardiogram and magnetic resonance imaging
| One year |
| Correlation of plasmatic levels of MicroRNAs with the serum levels of Pro-BNP. | One year |
| Correlation of plasmatic levels of MicroRNAs with the serum levels of TNF-alpha | One year |
| Correlation of plasmatic levels of MicroRNAs with the serum levels of IFN-gamma. | One year |
| D007239 |
| Infections |
| D000079426 | Vector Borne Diseases |