Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to analyze the efficacy of syndecan-4 as a biomarker on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of this molecule with functional and laboratory tests.
Increased serum levels of syndecan-4 have been correlated to acute myocardial infarction and chronic heart failure, suggesting that this molecule can be an important biomarker in heart diseases. In spite of that, there are no studies that have investigated the role of this molecule in chronic chagasic cardiomyopathy yet.
In this project, our objective is to demonstrate the potential role of syndecan-4 in the prognosis of chronic chagasic cardiomyopathy, seeking a better fitting of the treatment through the identification of patients with the worse prognosis.
The patients included in the study must at first sign the written consent. They shall be accompanied in the specialized outpatient clinics for Chagas disease - Hospital São Rafael - Centro de Biotecnologia e Terapia Celular. They will be submitted to several tests, including:
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Chagas disease diagnosis | Diagnosis of Chagas disease in both forms: indeterminate and cardiac ones, with and without ventricular dysfunction. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of plasmatic levels of syndecan-4 with the percentage of heart fibrosis | Mensuration of heart fibrosis percentage with Magnetic Resonance Imaging | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of plasmatic levels of syndecan-4 with the functional cardiovascular capacity | Mensuration of the functional capacity with treadmill test. | One year |
| Correlation of plasmatic levels of Syndecan-4 with the left ventricular function |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Tertiary Hospital
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Milena Botelho Pereira Soares, PhD | Hospital São Rafael | Principal Investigator |
| Ricardo Ribeiro dos Santos, MD | Hospital São Rafael | Study Director |
| Ticiana Ferreira Larocca, MD | Hospital São Rafael | Study Chair |
| Márcia Maria Noya Rabelo, MD | Hospital São Rafael | Study Chair |
| Luís Cláudio Lemos Correia, MD | Hospital São Rafael | Study Chair |
| Bruno Solano de Freitas Souza, MD | Hospital São Rafael | Study Chair |
| Carolina Thé Macedo, MD | Hospital São Rafael | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital São Rafael | Salvador | Estado de Bahia | 41253-190 | Brazil |
Not provided
| ID | Term |
|---|---|
| D014355 | Chagas Disease |
| ID | Term |
|---|---|
| D014352 | Trypanosomiasis |
| D056986 | Euglenozoa Infections |
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Plasma, Serum, Whole Blood
Mensuration of the left ventricular function with echocardiogram and magnetic resonance imaging
| One year |
| Correlation of plasmatic levels of Syndecan-4 with the serum levels of Pro-BNP. | One year |
| Correlation of plasmatic levels of Syndecan-4 with the serum levels of TNF-alpha | One year |
| Correlation of plasmatic levels of Syndecan-4 with the serum levels of IFN-gamma. | One year |
| D007239 |
| Infections |
| D000079426 | Vector Borne Diseases |