The purpose of this study is to determine the effect of repeated renal denervation in non-responding patients with severe hypertension. Therefore ultrasound technique will be used.

Renal Denervation is a CE-certified opportunity for treating patients with therapy-refractory hypertension. In some patients it doesn't show a significant lowering of the blood pressure, so a repeated renal denervation is an option.

In this study repeated renal denervation will be performed with the Recor Paradise Ultrasound Catheter.

For the study no specific procedures are required which would exceed the standard renal denervation procedure with the CE-certified Recor Paradise Ultrasound Catheter System.

There are no additional risks for the patient in consequence of participating in the study or the follow up procedures.

Inclusion Criteria:

• Individual is ≥18 years old
• Individual received renal denervation ≥12 months prior to study participation to no therapeutical avail and is scheduled for reintervention.
• Systolic Office based blood pressure ≥140mmHg
• Individual receives 3 or more antihypertensive drugs including one diuretic
• Individual is willing to provide written informed consent to participate in this study

Exclusion Criteria:

• Individual has hypertension secondary to an identifiable and treatable cause
• Individual has any serious medical condition which in the opinion of the investigator may adversely affect the participation.
• Individual is pregnant, nursing or planning to be pregnant
• Renal artery abnormalities which may affect the procedure

Patients with treatment-resistant hypertension, who already underwent renal denervation with no therapeutic avail.