The Enterprise decided to stop the production of the catheter used for the clinical indicated renal denervation

The study aimed to assess the success of a clinically indicated renal denervation by different tests and correlate the results of the tests with the clinical outcome.

We aim to test the response to adenosine infusion, cold pressure test, flow mediated dilation of renal artery before and after a clinical indicated renal denervation. Renal Denervation is not a study intervention

Inclusion Criteria:

Male and female patients 18 years to 85 years of age, with a diagnosis of re-sistant hypertension (office sitting blood pressure >140/90 mmHg and 24-hour blood pressure >130/80 mmHg in patients treated with at least three antihypertensive drugs including a diuretic) and a clinical indication for a renal denervation.

Exclusion Criteria:

• Secondary cause of hypertension
• Anatomical contraindication to renal denervation (renal artery diameter less than 4 mm or more than 8 mm), multiple renal artery, length to bifurcation less than 2 cm
• Heart failure (normal ejection fractions on echocardiography and no clinical signs and symptoms of heart failure).
• Alcohol or drug abuse,
• Malignancy (unless healed or remission > 5 years)
• Pregnancy
• Know allergy to contrast medium
• Participation in another study within the last month

Patient with therapy resistant hypertension and clinical indication for renal nerve ablation