The purpose of this study is to examine the benefit of renal sympathetic denervation in patients with mild refractory hypertension

Inclusion Criteria:

• Refractory hypertension: 3 or more antihypertensive agents of different classes (including a diuretic) at optimal dosage without change in the 4 weeks preceding randomization
• Systolic blood pressure of 135-149 and/or diastolic blood pressure of 90-94 mmHg (ABPM mean daytime values)
• No change in blood pressure medication within 6 months after randomization
• Age 18 to 75 years
• Informed consent

Exclusion Criteria:

• Blood pressure outside range mentioned above
• Renal, aortic or pelvic anatomy unsuited for renal sympathetic denervation
• Estimated glomerular filtration rate <45 mL/min/1.73 m² (modification of diet in renal disease formula)
• Unstable angina pectoris
• Myocardial infarction within 6 months prior to randomization
• Planned surgery or cardiovascular intervention within 6 months after randomization
• Severe heart valve disease
• Severe comorbidities with limited life expectancy
• Pregnancy
• Participation in another trial