Renal Denervation in Patients With Refractory Hypertension

Renal Denervation in Patients With Refractory Hypertension

To investigate the clinical utility of renal denervation in the treatment of refractory hypertension.

Inclusion Criteria:

• >= 18 years of age
• a systolic blood pressure of 160mmHg or more
• receiving and adhering to full doses of at least three antihypertensive drugs
• estimated glomerular filtration rate (eGFR) of ≥45mL/min
• agrees to have the study procedure(s) performed and additional procedures and evaluations
• is competent and willing to provide written, informed consent to participate in this clinical study

Exclusion Criteria:

• hemodynamically or anatomically significant renal artery stenosis
• has a history or prior renal artery angioplasty
• has experienced MI, unstable angina pectoris, or CVA within 6 months
• has hemodynamically significant valvular heart disease
• has Type 1 diabetes
• has an implantable cardioverter defibrillator (ICD) or pacemaker, or any other metallic implant which is not compatible with magnetic resonance imaging (MRI)
• requires respiratory support
• is pregnant, nursing, or planning to be pregnant
• has known, unresolved history of drug use or alcohol dependency.
• is currently enrolled in another investigational drug or device trial.