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The purpose of this study is to help understand the benefits of eating food supplemented with fiber in the form of sugarcane bagasse (the leftover fiber after cane juice is extracted) on glucose metabolism and body weight.
The investigators will employ a double-blind randomized controlled study design with 3 arms such that obese, insulin resistant adults will be randomly selected to receive food made with 1) sugarcane bagasse, 2) non-caloric, non-fermentable fiber, or 3) a similar product with minimal fiber for 4 weeks. The intervention will be in the form of brownies and cookies and will look and taste nearly identical to each other. Caloric value will be constant with all three delivery systems. Subjects will have blood testing and body composition analysis before and after the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sugarcane bagasse | Experimental | 10 subjects will consume food (brownies and cookies) made with 13 g of sugarcane bagasse everyday for 4 weeks |
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| Non-caloric, non-fermentable fiber | Active Comparator | 10 subjects will consume food (brownies and cookies) made with 13 g of non caloric, non-fermentable fiber everyday for 4 weeks |
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| Minimal fiber | Placebo Comparator | 10 subjects will consume food (brownies and cookies) made with 4 g of dietary fiber everyday for 4 weeks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sugarcane bagasse | Other | One brownie containing 10 g of sugarcane bagasse and 2 cookies containing 3 g of sugarcane bagasse (total of 13 g of sugarcane bagasse per day) |
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| Measure | Description | Time Frame |
|---|---|---|
| The benefit of sugarcane bagasse on glucose tolerance and insulin resistance in adults with established insulin resistance | Participants will be randomly selected to eat food supplemented with either 1) sugarcane bagasse, 2) another type of fiber of equal weight, or 3) minimal fiber. At baseline each eligible subject will have a 3 hour oral glucose tolerance test. Subjects will consume one brownie and two cookies a day for four weeks. At the end of four weeks, the blood tests conducted at baseline will be repeated. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of sugarcane bagasse on body weight/composition | At baseline and weekly till the end of the study, weight will be measured. In addition body composition via DXA will be measured at baseline and at the end of the study. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of sugarcane bagasse on incretin profiles as a mechanism to explain its metabolic effects | At baseline and at the end of the study, glucagon-like peptide-1 and ghrelin levels will be measured. | 4 Weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Hsia, MD | Pennington Biomedical Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | United States |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Non-caloric, non-fermentable fiber | Other | One brownie containing 10 g of fiber and 2 cookies containing 3 g of fiber (total of 13 g of non-caloric, non-fermentable fiber per day) |
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| Minimal fiber | Other | One brownie containing 3g of fiber and two cookies containing 1g of fiber (total of 4 g of dietary fiber per day) |
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