The main objective is to evaluate an osteopathic compression of pterygopalatine node in healthy subjects and patients suffering from obstructive apnea syndrome (OSA).

Osteopathic compression will be compared to a sham manoeuvre in a cross over design on apnea hypopnea index, pharyngeal collapsibility and symptoms in patients suffering from OSA, and on symptoms and pharyngeal collapsibility in healthy subjects.

Obstructive sleep apnea syndrome patient:

Inclusion criteria :

• Male or Female aged 18 years or more
• Obstructive sleep apnea syndrome with apnea/hypopnea index > or = 15/hour
• Body mass Index <40kg/m2

Exclusion criteria :

• Pregnant or lactating women
• Participating to another trial
• Acute infectious disease of upper respiratory airway tract at inclusion
• Complete nasal obstruction
• Facial neuralgia at inclusion
• Patients not able to stop treatment for OSA within one week before each visit
• Allergy to latex
• Dental extraction within 15 days before inclusion
• Pharyngeal surgery in the past
• Incapable adult
• Patients treated with Selective Serotonin Reuptake Inhibitor

Healthy Volunteers

Inclusion criteria :

• Male or Female aged ≥18 and ≤ 40 years
• No obstructive sleep apnea syndrome
• Body mass Index <30kg/m2
• No chronicle respiratory, neurological, cardiac or able to deteriorate sleep quality disease
• Low obstructive sleep apnea syndrome probability measured with Berlin Scale

Exclusion criteria :

• Pregnant or lactating women
• Participating to another trial
• Acute infectious disease of upper respiratory airway tract at inclusion
• Complete nasal obstruction
• Facial neuralgia at inclusion
• allergy to latex
• dental extraction within 15 days before inclusion
• pharyngeal surgery in the past
• incapable adult
• patients treated background treatment