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The aim of the study is to test the accuracy of Regadenoson to induce maximal and steady state hyperemia as compared to central venous infusion of adenosine for assessing fractional flow reserve. (adenosine is considered to be the gold standard)and to investigate the time intervals of maximum hyperemia induced by centrally and peripherally administered Regadenoson.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Regadenoson central - peripheral | Active Comparator | First bolus regadenoson administered central, second bolus administered peripheral |
|
| Regadenoson peripheral - central | Active Comparator | First bolus regadenoson administered peripheral, second bolus administered central |
|
| Regadenoson central - central | Active Comparator | First bolus regadenoson administered central, second bolus administered central |
|
| Regadenoson peripheral - peripheral | Active Comparator | First bolus regadenoson administered peripheral, second bolus administered peripheral |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Regadenoson central -central | Drug | To test the accuracy of Regadenoson to induce maximal and steady state hyperemia as compared to central venous infusion of adenosine for assessing fractional flow reserve. (adenosine is considered to be the golden standard). |
| Measure | Description | Time Frame |
|---|---|---|
| the accuracy of Regadenoson to induce maximal and steady state hyperemia | To test the accuracy of Regadenoson to induce maximal and steady state hyperemia as compared to central venous infusion of adenosine for assessing fractional flow reserve. (adenosine is considered to be the gold standard). | participants will be followed up during hospital stay, an expected average of 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| time intervals of maximum hyperemia | To investigate the time intervals of maximum hyperemia induced by centrally and peripherally administered Regadenoson. | participants will be followed up during hospital stay, an expected average of 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nico H.J. Pijls, MD, PhD | Catharina Ziekenhuis Eindhoven | Principal Investigator |
| Lokien X van Nunen, MD | Catharina Ziekenhuis Eindhoven | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Catharina Hospital | Eindhoven | North Brabant | 5623 EJ | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25136887 | Derived | van Nunen LX, Lenders GD, Schampaert S, van 't Veer M, Wijnbergen I, Brueren GR, Tonino PA, Pijls NH. Single bolus intravenous regadenoson injection versus central venous infusion of adenosine for maximum coronary hyperaemia in fractional flow reserve measurement. EuroIntervention. 2015 Dec;11(8):905-13. doi: 10.4244/EIJY14M08_10. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000241 | Adenosine |
| ID | Term |
|---|---|
| D011684 | Purine Nucleosides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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| Regadenoson peripheral - peripheral | Drug | To test the accuracy of Regadenoson to induce maximal and steady state hyperemia as compared to central venous infusion of adenosine for assessing fractional flow reserve. (adenosine is considered to be the golden standard). |
|
| Regadenoson central - peripheral | Drug | To test the accuracy of Regadenoson to induce maximal and steady state hyperemia as compared to central venous infusion of adenosine for assessing fractional flow reserve. (adenosine is considered to be the golden standard). |
|
| Regadenoson peripheral - central | Drug | To test the accuracy of Regadenoson to induce maximal and steady state hyperemia as compared to central venous infusion of adenosine for assessing fractional flow reserve. (adenosine is considered to be the golden standard). |
|
| Adenosine | Drug | Fractional flow reserve is measured by inducing hyperaemia using central adenosine infusion. |
|
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D006571 | Heterocyclic Compounds |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012263 | Ribonucleosides |