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| Name | Class |
|---|---|
| Seoul National University Boramae Hospital | OTHER |
| Inje University Ilsan Paik Hospital | OTHER |
| Keimyung University Dongsan Medical Center | OTHER |
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The purpose of this study is to evaluate the efficacy of nicorandil in the achievement of maximal coronary hyperemia compared with adenosine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adenosine Followed by Nicorandil | Experimental |
| |
| Nicorandil Followed by Adenosine | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Maximal Hyperemia with Adenosine Followed by Nicorandil | Other | Firstly FFR was measured with intravenous adenosine infusion (140 μg•min-1•kg-1) via femoral vein or antecubital vein. Secondly with intracoronary adenosine bolus injection (80μg, 40μg to LCA and RCA, respectively). Lastly with intracoronary nicorandil bolus injection (1mg followed by 2mg). |
| Measure | Description | Time Frame |
|---|---|---|
| Fractional Flow Reserve at Maximal Hyperemia | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Time to Maximal Hyperemia | 1 day | |
| Changes in Heart Rate | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ho-Jun Jang, MD | Contact | 82-2-2072-3757 | wingal@naver.com | |
| Bon-Kwan Koo, MD.PhD | Contact | 82-2-2072-2062 | bkkoo@snu.ac.kr |
| Name | Affiliation | Role |
|---|---|---|
| Bon-Kwon Koo, MD. PhD | Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular Center, Seoul National University Hospital | Recruiting | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23396491 | Derived | Jang HJ, Koo BK, Lee HS, Park JB, Kim JH, Seo MK, Yang HM, Park KW, Nam CW, Doh JH, Kim HS. Safety and efficacy of a novel hyperaemic agent, intracoronary nicorandil, for invasive physiological assessments in the cardiac catheterization laboratory. Eur Heart J. 2013 Jul;34(27):2055-62. doi: 10.1093/eurheartj/eht040. Epub 2013 Feb 8. |
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|
| Maximal Hyperemia with Nicorandil Followed by Adenosine | Other | Firstly FFR was measured with intracoronary nicorandil bolus injection (1mg followed by 2mg). Secondly with intravenous adenosine infusion (140 μg•min-1•kg-1) via femoral vein or antecubital vein. Lastly with intracoronary adenosine bolus injection (80μg, 40μg to LCA and RCA, respectively). |
|
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D017202 | Myocardial Ischemia |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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