Major Inclusion Criteria:
- Male or female subjects between 30 years and 65 years
- Wrinkle score of at least 2 according to the Modified Fitzpatrick Wrinkle Scale (MFWS)
Major Exclusion Criteria:
- For females: pregnancy, lactating, planned pregnancy or unwilling to use contraceptives
- History of allergic reaction to hyaluronic acid products
- Facial surgery or implantation of dermal fillers in the nasolabial region within the last 24 months
- Skin of the nasolabial region affected by cosmetic treatments (e.g. laser therapy within the last 12 months, chemical peeling within the last 3 months, dermabrasion within the last 12 months, botulinum toxin within the last 12 months )
- Connective tissue diseases
- Diabetes mellitus or uncontrolled systemic diseases
- Known human immune deficiency virus-positive individuals
- Presence of silicone implant or another non-absorbable substance (permanent fillers) in the area of product application
- Cutaneous lesions in the evaluated area
- Tendency to keloid formation and/or hypertrophic scars
- Autoimmune disease
- History of allergies against cosmetic filling products and re-current herpes simplex
- History of immune system degradation