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| Name | Class |
|---|---|
| Mitacs | INDUSTRY |
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Bovine colostrum is the initial milk secreted by cows during the first day after calving. Colostrum is high in protein and contains a number of substances that have potential to be beneficial for the immune system. Preliminary studies about effects of colostrum supplementation show its potential for increasing human exercise performance; however, more evidence across the lifespan is required to confirm effects and to understand mechanisms of action. The objectives are to determine the effect of 8 weeks of bovine colostrum supplementation, compared to whey protein supplementation on the following dependent variables in men and women 50 years and older while participating in a resistance-training program:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bovine Colostrum | Experimental | 60 g/d bovine colostrum in powder form to be mixed with drinks. The dose will be spread out 3 times per day (20 g per dose) |
|
| Whey protein | Active Comparator | 60 g/d whey protein powder mixed into drinks. It is to be divided into 3 daily doses (20 g per dose) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bovine colostrum | Dietary Supplement |
| ||
| Whey protein |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in lean tissue mass at 8 weeks | Lean tissue mass assessed by dual energy x-ray absorptiometry | baseline and 8 weeks |
| Change from baseline in Upper body strength at 8 weeks | Bench Press Strength | baseline and 8 weeks |
| Change from baseline in Lower body strength at 8 weeks | Leg press strength | baseline and 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Insulin like growth factor-1 at 8 weeks | IGF-1 from serum | baseline and 8 weeks |
| Change from baseline in upper body muscle thickness at 8 weeks | Muscle thickness of the elbow flexors assessed by ultrasound |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philip D Chilibeck, PhD | University of Saskatchewan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| College of Kinesiology, University of Saskatchewan | Saskatoon | Saskatchewan | S7N 5B2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11312068 | Background | Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. 2001 Mar;17(3):243-7. doi: 10.1016/s0899-9007(00)00552-9. | |
| 17679046 | Background | Kerksick CM, Rasmussen C, Lancaster S, Starks M, Smith P, Melton C, Greenwood M, Almada A, Kreider R. Impact of differing protein sources and a creatine containing nutritional formula after 12 weeks of resistance training. Nutrition. 2007 Sep;23(9):647-56. doi: 10.1016/j.nut.2007.06.015. |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D010024 | Osteoporosis |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000067816 | Whey Proteins |
| ID | Term |
|---|---|
| D008894 | Milk Proteins |
| D000080224 | Animal Proteins, Dietary |
| D004044 | Dietary Proteins |
| D011506 | Proteins |
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|
| baseline and 8 weeks |
| Change from baseline in lower body muscle thickness at 8 weeks | Knee extensors muscle thickness assessed by ultrasound | baseline and 8 weeks |
| Change from baseline in muscle catabolism at 8 weeks | Urinary 3-methylhistidine levels | baseline and 8 weeks |
| Change from baseline in bone catabolism at 8 weeks | Urinary cross-linked N-telopeptides of type I collagen | Baseline and 8 weeks |
| Number of Participants with Adverse Events as a Measure of Safety and Number of Participants with Adverse Events as a Measure of Safety and Tolerability | Adverse events collected on adverse event forms | continuously throughout 8 weeks |
| Change from baseline in inflammation at 8 weeks | Serum cytokine markers of inflammation (IL-6 and TNF-alpha) | baseline and 8 weeks |
| Change from baseline in cognitive ability at 8 weeks | The Telephone Interview of Cognitive Status | baseline and 8 weeks |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D010335 | Pathologic Processes |
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D000067796 | Whey |
| D008892 | Milk |
| D003611 | Dairy Products |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |