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Prospective randomized comparison of two widely used in vitro culture system in human IVF treatments. In vitro fertilized oocytes and embryos are cultured in individual culture media droplets using conventional petridish or in group culture using WOW (well of the well) petridish.
Primary outcome: implantation and pregnancy rates Secondary outcome: fertilization rate and embryo quality
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group culture | Embryos cultured in groups of 2-10 |
| |
| Individual culture | Embryos cultured individually |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| individual embryo culture or group culture | Other | Embryos cultured in a 25 microliter droplet of culture media individually in a conventional petridish or in groups of 2-10 embryos in a Well-of-the-Well petridish |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Number of clinical pregnancies (/No. of embryo transfers) | 4 weeks after the embryo transfer |
| Implantation rate | Number of embryos implanted (/number of embryos transferred) | 4 weeks after embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| Fertilization rate | Number of oocytes fertilized. (only in intracytoplasmic sperm injection cycles) | 18 hours after sperm injection |
| Embryo quality | Number and quality of blastomeres, amount of fragmentation embryo grade |
| Measure | Description | Time Frame |
|---|---|---|
| Time needed for evaluation of zygotes and embryos | 18, 24, 36 and 72 hours after fertilization |
Inclusion Criteria:
Exclusion Criteria:
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Patients entering in vitro fertilization and embryo transfer treatment
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| Name | Affiliation | Role |
|---|---|---|
| Janos Urbancsek, DSc | Semmelweis University First Department of Obstetrics and Gynecology | Principal Investigator |
| Peter Fancsovits, Ph.D. | Semmelweis University First Department of Obstetrics and Gynecology | Study Chair |
| Csaba Pribenszky, Ph.D. | University of Veterinary Sciences, Budapest | Principal Investigator |
| Adam Lehner, MSc | Semmelweis University First Department of Obstetrics and Gynecology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Semmelweis University First Department of Obstetrics and Gynecology | Budapest | 1088 | Hungary |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35278201 | Derived | Fancsovits P, Pribenszky C, Lehner A, Murber A, Kaszas Z, Nemes A, Urbancsek J. Prospective-randomized study comparing clinical outcomes of IVF treatments where embryos were cultured individually or in a microwell group culture dish. Biol Futur. 2022 Jun;73(2):229-236. doi: 10.1007/s42977-022-00113-8. Epub 2022 Mar 12. |
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| 36 and 72 hours after fertilization |