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Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| phenolic acids | Experimental | Maltodextrine + Phenolic acids |
|
| placebo | Placebo Comparator | Maltodextrine |
|
| phenolic acid | Experimental | Maltodextrine + Phenolic acids |
|
| polyphenol | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phenolic acids | Other | Phenolic acids |
|
| Measure | Description | Time Frame |
|---|---|---|
| endothelial dysfunction | 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
Any food allergy
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| Name | Affiliation | Role |
|---|---|---|
| Yves Allemann, MD, Prof. | University Hospital, Bern, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Swiss Cardiovascular Center Bern, University Hospital | Bern | 3010 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28012692 | Derived | Mills CE, Flury A, Marmet C, Poquet L, Rimoldi SF, Sartori C, Rexhaj E, Brenner R, Allemann Y, Zimmermann D, Gibson GR, Mottram DS, Oruna-Concha MJ, Actis-Goretta L, Spencer JPE. Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. Clin Nutr. 2017 Dec;36(6):1520-1529. doi: 10.1016/j.clnu.2016.11.013. Epub 2016 Nov 30. |
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