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| Name | Class |
|---|---|
| Children's Hospital of Fudan University | OTHER |
| Nanjing Maternity and Child Health Care Hospital | OTHER |
| First Affiliated Hospital of Harbin Medical University | OTHER |
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Thirteen hospitals in China will participate in the study, which aims to provide data on transcutaneous bilirubin (TcB) levels for the first 168 hr after birth in term and late-preterm neonates, and develop an hour-specific TcB nomogram.
The investigators hypothesize that the hour-specific TcB nomogram can predict neonatal hyperbilirubinemia in term and late-preterm Chinese infants, and plan appropriate follow-up for hyperbilirubinemia in newborns.
Neonatal hyperbilirubinemia is very common; it is not always a benign condition. If left untreated, it can have devastating consequences including cerebral palsy and hearing loss. It is therefore critical to be able to identify the newborns at risk for severe hyperbilirubinemia.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcutaneous bilirubinometry | Device | Device: JM-103 (Minolta, Osaka, Japan, jaundice assessment) Procedure: Transcutaneous bilirubinometry (TcB) |
| Measure | Description | Time Frame |
|---|---|---|
| Change of transcutaneous bilirubin levels from baseline to each postpartum examination up to 168 hr after birth | During the first postnatal day, transcutaneous bilirubin (TcB) measures were performed at 12-hour time intervals up to the age of 168 hr. TcB data are used to develop an hour-specific TcB nomogram. | Every 12 hr for 168 hr. |
| Measure | Description | Time Frame |
|---|---|---|
| Predictive ability of an hour-specific TcB nomogram | Evaluate the rate of rise of bilirubin for different time periods and percentile curves and to assess predictive ability of these percentile curves for hyperbilirubinemia, defined as requirement of phototherapy. | At the 28 days after birth |
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Inclusion Criteria:
Term or late-preterm newborn infants with GAs of ≥35 weeks and birth weights of ≥2,000 g were included.
Exclusion Criteria:
All sick newborn infants who were admitted to the intensive care unit.
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Term or late-preterm newborn infants from thirteen hospital in China were recruited.
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| Name | Affiliation | Role |
|---|---|---|
| Chao Chen, PhD | Children's Hospital of Fudan University | Study Director |
| Shuping Han, PhD | Nanjing Maternity and Child Health Care Hospital | Study Director |
| Zhangbin Yu, PhD | Nanjing Maternity and Child Health Care Hospital | Principal Investigator |
| Chunming Jiang, PhD | First Affiliated Hospital of Harbin Medical University | Principal Investigator |
| Yan Gao, PhD | Jinlin Provincial Maternal and Child Health Hospital | Principal Investigator |
| Xiaomei Tong, PhD | Peking University Third Hospital | Principal Investigator |
| Meihua Pu, PhD | Peking University Third Hospital | Principal Investigator |
| Hongyun Wang, PhD | Inner Mongolia Maternal and Child Health Care Hospital | Principal Investigator |
| Kezhan Liu, PhD | Shanxi Provincial Maternity and Children's Hospital |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangdong Maternal and Children's Hospital, Guangzhou Medical College | Guangzhou | Guangdong | 510010 | China | ||
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| Jinlin Provincial Maternal and Child Health Hospital |
| UNKNOWN |
| Peking University Third Hospital | OTHER |
| Inner Mongolia Maternal and Child Health Care Hospital | OTHER |
| Shanxi Provincial Maternity and Children's Hospital | OTHER |
| Obstetrics & Gynecology Hospital of Fudan University | OTHER |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| Guangdong Women and Children Hospital | OTHER |
| Guangxi Maternal and Child Health Hospital | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| Sichuan Provincial People's Hospital | OTHER |
| Guiyang Maternity and Child Health Care Hospital | OTHER |
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| Jin Wang, PhD | Children's Hospital of Fudan University | Principal Investigator |
| Jimei Wang, PhD | Obstetrics & Gynecology Hospital of Fudan University | Principal Investigator |
| Xiuyong Cheng, PhD | The First Affiliated Hospital of Zhengzhou University | Principal Investigator |
| Jie Yang, PhD | Guangdong Women and Children Hospital | Principal Investigator |
| Qiufen Wei, PhD | Guangxi Maternal and Child Health Hospital | Principal Investigator |
| Zhankui Li, PhD | Shanxi Provincial Maternity and Children's Hospital | Principal Investigator |
| Mingxia Li, PhD | First Affiliated Hospital of Xinjiang Medical University | Principal Investigator |
| Ling Liu, PhD | Guiyang Maternity and Child Health Care Hospital | Principal Investigator |
| Xiaofan Sun, MD | Nanjing Maternity and Child Health Care Hospital | Principal Investigator |
| Guangxi Maternal and Child Health Hospital |
| Liuzhou |
| Guangxi |
| 530003 |
| China |
| Guiyang Maternal and Child Health Hospital | Guiyang | Guizhou | 550003 | China |
| The First Hospital of Harbin Medical University | Harbin | Heilongjiang | 150001 | China |
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou | Henan | 410100 | China |
| Inner Mongolia Maternal and Child Health Care Hospital | Hohhot | Inner Mongolia | 010020 | China |
| Nanjing Maternity and Child Health Care Hospital of Nanjing Medical University | Nanjing | Jiangsu | 210004 | China |
| Jinlin Provincial Maternal and Child Health Hospital | Changchun | Jilin | 130021 | China |
| Shaanxi Provincial Maternal and Child Health Hospital | Taiyuan | Shaanxi | 300013 | China |
| Shaanxi Provincial Maternal and Child Health Hospital | Xi'an | Shaanxi | 710003 | China |
| Sichuan Provincial People's Hospital | Chengdu | Sichuan | 610072 | China |
| Sichuan Provincial People's Hospital | Chengdu | Sichuan | China |
| The First Hospital of Xinjiang Medical University | Ürümqi | Xinjiang | 830054 | China |
| The Third Hospital of Peking University | Beijing | 100191 | China |
| Gynecology and Obstetrics Hospital, Fudan University | Shanghai | 200011 | China |
| Children's Hospital of Fudan University | Shanghai | 200032 | China |
| ID | Term |
|---|---|
| D051556 | Hyperbilirubinemia, Neonatal |
| D006932 | Hyperbilirubinemia |
| ID | Term |
|---|---|
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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