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| Name | Class |
|---|---|
| Children's Hospital of Fudan University | OTHER |
| Nanjing Maternity and Child Health Care Hospital | OTHER |
| Jinlin Provincial Maternal and Child Health Hospital | UNKNOWN |
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Thirteen hospitals in China will participate in the study, which aims to provide data on serum bilirubin levels in the first 168 hr after birth in term and late-preterm neonates, and estimate the incidence of severe neonatal hyperbilirubinemia and the underlying causes.
We hypothesize that the study can be value in identifying and implementing strategies for risk reduction.
Neonatal hyperbilirubinemia resulting in clinical jaundice is a common problem among infants, particularly during the first weeks of life.
Information about the incidence and risk factors of neonatal jaundice is not available from China where is one of the highest countries of the incidence of severe neonatal hyperbilirubinemia.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phototherapy | Procedure | The decision to use phototherapy conformed to the hour-specific threshold value for phototherapy presented by the American Academy of Pediatrics guidelines and was not at the discretion of the investigators. |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of severe neonatal hyperbilirubinemia | Significant hyperbilirubinemia was defined as any TSB level that exceeded the hour-specific threshold value for phototherapy, according to the guidelines presented by the American Academy of Pediatrics. | At the 28 days after birth |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with risk factors associated with severe neonatal hyperbilirubinemia | The risk factors recognized to be associated with significant hyperbilirubinemia in newborns have included gestational age, weight for Gestational Age, delivery mode, gender, previous infant had phototherapy, bruising/cephalahematoma, feeding mode, excessive body weight loss, and early discharge, et al. | At the 28 days after birth |
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Inclusion Criteria:
Term or late-preterm newborn infants with GAs of ≥35 weeks and birth weights of ≥2,000 g were included.
Exclusion Criteria:
All sick newborn infants who were admitted to the intensive care unit.
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Term or late-preterm newborn infants from Seventeen hospitals in China were recruited.
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| Name | Affiliation | Role |
|---|---|---|
| Chao Chen, PhD | Children's Hospital of Fudan University | Study Director |
| Shuping Han, PhD | Nanjing Maternity and Child Health Care Hospital | Study Director |
| Zhangbin Yu, PhD | Nanjing Maternity and Child Health Care Hospital | Principal Investigator |
| Chunming Jiang, PhD | First Affiliated Hospital of Harbin Medical University | Principal Investigator |
| Yan Gao, PhD | Jinlin Provincial Maternal and Child Health Hospital | Principal Investigator |
| Xiaomei Tong, PhD | Peking University Third Hospital | Principal Investigator |
| Meihua Pu, PhD | Peking University Third Hospital | Principal Investigator |
| Hongyun Wang, PhD | Inner Mongolia Maternal and Child Health Care Hospital | Principal Investigator |
| Kezhan Liu, PhD | Shanxi Provincial Maternity and Children's Hospital |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangdong Maternal and Children's Hospital, Guangzhou Medical College | Guangzhou | Guangdong | 510010 | China | ||
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| ID | Term |
|---|---|
| D051556 | Hyperbilirubinemia, Neonatal |
| D006932 | Hyperbilirubinemia |
| ID | Term |
|---|---|
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D010789 | Phototherapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| Peking University Third Hospital |
| OTHER |
| Inner Mongolia Maternal and Child Health Care Hospital | OTHER |
| Shanxi Provincial Maternity and Children's Hospital | OTHER |
| Obstetrics & Gynecology Hospital of Fudan University | OTHER |
| Guangdong Women and Children Hospital | OTHER |
| Guangxi Maternal and Child Health Hospital | OTHER |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| First Affiliated Hospital of Harbin Medical University | OTHER |
| Sichuan Provincial People's Hospital | OTHER |
| Guiyang Maternity and Child Health Care Hospital | OTHER |
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| Jin Wang, PhD | Children's Hospital of Fudan University | Principal Investigator |
| Jimei Wang, PhD | Obstetrics & Gynecology Hospital of Fudan University | Principal Investigator |
| Xiuyong Cheng, PhD | The First Affiliated Hospital of Zhengzhou University | Principal Investigator |
| Jie Yang, PhD | Guangdong Women and Children Hospital | Principal Investigator |
| Qiufen Wei, PhD | Guangxi Maternal and Child Health Hospital | Principal Investigator |
| Zhankui Li, PhD | Shanxi Provincial Maternity and Children's Hospital | Principal Investigator |
| Mingxia Li, PhD | First Affiliated Hospital of Xinjiang Medical University | Principal Investigator |
| Changhui Chen, PhD | Sichuan Provincial People's Hospital | Principal Investigator |
| Ling Liu, PhD | Guiyang Maternity and Child Health Care Hospital | Principal Investigator |
| Xiaofan Sun, MD | Nanjing Maternity and Child Health Care Hospital | Principal Investigator |
| Guangxi Maternal and Child Health Hospital |
| Liuzhou |
| Guangxi |
| 530003 |
| China |
| Guiyang Maternal and Child Health Hospital | Guiyang | Guizhou | 550003 | China |
| The First Hospital of Harbin Medical University | Harbin | Heilongjiang | 150001 | China |
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou | Henan | 410100 | China |
| Inner Mongolia Maternal and Child Health Care Hospital | Hohhot | Inner Mongolia | 010020 | China |
| Nanjing Maternity and Child Health Care Hospital of Nanjing Medical University | Nanjing | Jiangsu | 210004 | China |
| Jinlin Provincial Maternal and Child Health Hospital | Changchun | Jilin | 130021 | China |
| Shaanxi Provincial Maternal and Child Health Hospital | Taiyuan | Shaanxi | 300013 | China |
| Sichuan Provincial People's Hospital | Chengdu | Sichuan | 610072 | China |
| The First Hospital of Xinjiang Medical University | Ürümqi | Xinjiang | 830054 | China |
| The Third Hospital of Peking University | Beijing | 100191 | China |
| Gynecology and Obstetrics Hospital, Fudan University | Shanghai | 200011 | China |
| Children's Hospital of Fudan University | Shanghai | 200032 | China |