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The purpose of this study is to evaluate the effects of regular low fat diary consumption on markers of cardiovascular (CV) and metabolic (cardiometabolic) health including body composition (% body fat, body weight), blood lipids, blood glucose, arterial compliance, blood pressure, insulin sensitivity and resting metabolic rate.
This is a multi-centre, randomized, dietary intervention study of 12 months. A total of 100 overweight/obese individuals will be recruited, half recruited in Adelaide, South Australia and the other half from Manitoba, Canada. At baseline, subjects assigned to HD will be given standard serves of low fat dairy products (eg. 250mL milk, 200g yoghurt) on a regular basis for 6 months and asked to incorporate 4 serves/day into their diet. Volunteers randomized to the LD will be asked to continue with their habitual diet and consume less than 2 serves of dairy on a regular basis for 6 months. All participants will be asked to complete a food frequency questionnaire, physical activity diary, 3-day food record, and keep a record of dairy serves (food log) consumed each day. In total, participants will be asked to come to the centre 5 times throughout the study. However, the HD group will be asked to return to the centre every two weeks to receive diary product and return dairy record (food log). At baseline subjects will be asked to attend the Richardson Centre for Functional Foods and Nutraceuticals (RCFFN) fasted for various measurements including: body weight, blood pressure, arterial compliance, dual energy x-ray absorptiometry (DEXA) scan for measurement of body fat, abdominal fat and bone mineral density, waist and hip circumferences and provide a blood sample for the measurement of blood lipids, insulin and glucose.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Dairy | Experimental | Consuming four or more servings of dairy per day. |
|
| Control, Low Dairy | Placebo Comparator | Participants consumed less than 2 servings of low fat dairy per day. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Dairy | Other | Consuming 4 or more servings of dairy products per day for a period of 6 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| markers of metabolic (cardiometabolic) health |
| Six Months |
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Inclusion Criteria:
BMI ≥25 kg/m2, assessed as age-related healthy based on pre-study screening examination including:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Curtis Rempel, PhD, MBA | University of Manitoba | Principal Investigator |
| Gary Fulcher, PhD | University of Manitoba | Study Chair |
| Peter JH Jones, PhD | University of Manitoba | Study Director |
| Rotimi Aluko, PhD | University of Manitoba | Study Chair |
| Thomas Netticadan, PhD | University of Manitoba | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Richardson Centre for Functional Foods and Nutraceuticals | Winnipeg | Manitoba | R3T 2N2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23638799 | Derived | Rideout TC, Marinangeli CP, Martin H, Browne RW, Rempel CB. Consumption of low-fat dairy foods for 6 months improves insulin resistance without adversely affecting lipids or bodyweight in healthy adults: a randomized free-living cross-over study. Nutr J. 2013 May 2;12:56. doi: 10.1186/1475-2891-12-56. |
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| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D009765 | Obesity |
| D001835 | Body Weight |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |